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Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1

A major barrier to successful pancreatic cancer (PC) treatment is the surrounding stroma, which secretes growth factors/cytokines that promote PC progression. Wnt and tenascin C (TnC) are key ligands secreted by stromal pancreatic stellate cells (PSCs) that then act on PC cells in a paracrine manner...

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Detalles Bibliográficos
Autores principales:	Geleta, Bekesho, Tout, Faten S., Lim, Syer Choon, Sahni, Sumit, Jansson, Patric J., Apte, Minoti V., Richardson, Des R., Kovačević, Žaklina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881656/ https://www.ncbi.nlm.nih.gov/pubmed/35065073 http://dx.doi.org/10.1016/j.jbc.2022.101608

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