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On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity

Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many studies have shed light into the pathobiology of PDAC, the nature of PDAC’s cell of origin remains under debate. Studies in adult pancreatic tissue have unveiled a remarkable exocrine cell plasticity including transi...

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Autores principales: Backx, Elyne, Coolens, Katarina, Van den Bossche, Jan-Lars, Houbracken, Isabelle, Espinet, Elisa, Rooman, Ilse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881661/
https://www.ncbi.nlm.nih.gov/pubmed/34875393
http://dx.doi.org/10.1016/j.jcmgh.2021.11.010
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author Backx, Elyne
Coolens, Katarina
Van den Bossche, Jan-Lars
Houbracken, Isabelle
Espinet, Elisa
Rooman, Ilse
author_facet Backx, Elyne
Coolens, Katarina
Van den Bossche, Jan-Lars
Houbracken, Isabelle
Espinet, Elisa
Rooman, Ilse
author_sort Backx, Elyne
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many studies have shed light into the pathobiology of PDAC, the nature of PDAC’s cell of origin remains under debate. Studies in adult pancreatic tissue have unveiled a remarkable exocrine cell plasticity including transitional states, mostly exemplified by acinar to ductal cell metaplasia, but also with recent evidence hinting at duct to basal cell transitions. Single-cell RNA sequencing has further revealed intrapopulation heterogeneity among acinar and duct cells. Transcriptomic and epigenomic relationships between these exocrine cell differentiation states and PDAC molecular subtypes have started to emerge, suggesting different ontogenies for different tumor subtypes. This review sheds light on these diverse aspects with particular focus on studies with human cells. Understanding the “masked ball” of exocrine cells at origin of PDAC and leaving behind the binary acinar vs duct cell classification may significantly advance our insights in PDAC biology.
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spelling pubmed-88816612022-03-02 On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity Backx, Elyne Coolens, Katarina Van den Bossche, Jan-Lars Houbracken, Isabelle Espinet, Elisa Rooman, Ilse Cell Mol Gastroenterol Hepatol Review Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many studies have shed light into the pathobiology of PDAC, the nature of PDAC’s cell of origin remains under debate. Studies in adult pancreatic tissue have unveiled a remarkable exocrine cell plasticity including transitional states, mostly exemplified by acinar to ductal cell metaplasia, but also with recent evidence hinting at duct to basal cell transitions. Single-cell RNA sequencing has further revealed intrapopulation heterogeneity among acinar and duct cells. Transcriptomic and epigenomic relationships between these exocrine cell differentiation states and PDAC molecular subtypes have started to emerge, suggesting different ontogenies for different tumor subtypes. This review sheds light on these diverse aspects with particular focus on studies with human cells. Understanding the “masked ball” of exocrine cells at origin of PDAC and leaving behind the binary acinar vs duct cell classification may significantly advance our insights in PDAC biology. Elsevier 2021-12-04 /pmc/articles/PMC8881661/ /pubmed/34875393 http://dx.doi.org/10.1016/j.jcmgh.2021.11.010 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Backx, Elyne
Coolens, Katarina
Van den Bossche, Jan-Lars
Houbracken, Isabelle
Espinet, Elisa
Rooman, Ilse
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title_full On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title_fullStr On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title_full_unstemmed On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title_short On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
title_sort on the origin of pancreatic cancer: molecular tumor subtypes in perspective of exocrine cell plasticity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881661/
https://www.ncbi.nlm.nih.gov/pubmed/34875393
http://dx.doi.org/10.1016/j.jcmgh.2021.11.010
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