Cargando…
Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma
BACKGROUND: The roles of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in solid tumors are well established. However, the interaction between CSCs and EMT in pulmonary large cell neuroendocrine carcinoma (LCNEC) remains unknown. The aim of this study was to investigate the exp...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881670/ https://www.ncbi.nlm.nih.gov/pubmed/35219092 http://dx.doi.org/10.1016/j.tranon.2022.101379 |
_version_ | 1784659525652971520 |
---|---|
author | Zhang, Jinyao Sun, Xujie Liu, Li Dong, Jiyan Deng, Lei Wang, Xin Guo, Yiying Ying, Jianming Xing, Puyuan Li, Junling Yang, Lin |
author_facet | Zhang, Jinyao Sun, Xujie Liu, Li Dong, Jiyan Deng, Lei Wang, Xin Guo, Yiying Ying, Jianming Xing, Puyuan Li, Junling Yang, Lin |
author_sort | Zhang, Jinyao |
collection | PubMed |
description | BACKGROUND: The roles of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in solid tumors are well established. However, the interaction between CSCs and EMT in pulmonary large cell neuroendocrine carcinoma (LCNEC) remains unknown. The aim of this study was to investigate the expression and clinical significance of a CSC marker (ALDH1A1) and its correlation with Epithelial-like phenotype marker (E-cadherin) and Mesenchymal-like phenotype marker (N-cadherin) in LCNEC patients. METHODS: Immunohistochemistry (IHC) for ALDH1A1, E-cadherin and N-cadherin expression was conducted on tissue microarrays made from 79 resected LCNEC patient samples. ALDH1A1 protein expression was evaluated by the IHC score, and its correlations with the expression of E-cadherin, N-cadherin and clinicopathological features were determined based on IHC data. Survival analyses were also performed. RESULTS: ALDH1A1 was positively expressed in 75.9% (60/79 cases) of LCNEC patients. No significant difference in clinicopathological variables was observed between the ALDH1A1-negative and ALDH1A1-positive groups. However, ALDH1A1 expression was positively correlated with E-cadherin (Spearman's rho = 0.229, p-value = 0.007), which represents the epithelial-like phenotype, but not with N-cadherin. Patients with expression of ALDH1A1 had significantly longer disease-free survival (DFS) and overall survival (OS) than those who were ALDH1A1 negative (median DFS: 52 vs 12 months, p = 0.028; median OS: not reached; p = 0.027). Multivariate analysis showed that ALDH1A1 was an independent favorable prognostic factor for DFS (p = 0.032, HR: 0.438, 95% CI: 0.206–0.932) and OS (p = 0.025, HR: 0.279, 95% CI: 0.091–0.852) in LCNEC patients. CONCLUSION: This study suggests that ALDH1A1 can act as a favorable independent prognostic factor for LCNEC, which related to the epithelioid phenotype in EMT, and its internal mechanism needs further study. |
format | Online Article Text |
id | pubmed-8881670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88816702022-03-02 Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma Zhang, Jinyao Sun, Xujie Liu, Li Dong, Jiyan Deng, Lei Wang, Xin Guo, Yiying Ying, Jianming Xing, Puyuan Li, Junling Yang, Lin Transl Oncol Commentary BACKGROUND: The roles of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in solid tumors are well established. However, the interaction between CSCs and EMT in pulmonary large cell neuroendocrine carcinoma (LCNEC) remains unknown. The aim of this study was to investigate the expression and clinical significance of a CSC marker (ALDH1A1) and its correlation with Epithelial-like phenotype marker (E-cadherin) and Mesenchymal-like phenotype marker (N-cadherin) in LCNEC patients. METHODS: Immunohistochemistry (IHC) for ALDH1A1, E-cadherin and N-cadherin expression was conducted on tissue microarrays made from 79 resected LCNEC patient samples. ALDH1A1 protein expression was evaluated by the IHC score, and its correlations with the expression of E-cadherin, N-cadherin and clinicopathological features were determined based on IHC data. Survival analyses were also performed. RESULTS: ALDH1A1 was positively expressed in 75.9% (60/79 cases) of LCNEC patients. No significant difference in clinicopathological variables was observed between the ALDH1A1-negative and ALDH1A1-positive groups. However, ALDH1A1 expression was positively correlated with E-cadherin (Spearman's rho = 0.229, p-value = 0.007), which represents the epithelial-like phenotype, but not with N-cadherin. Patients with expression of ALDH1A1 had significantly longer disease-free survival (DFS) and overall survival (OS) than those who were ALDH1A1 negative (median DFS: 52 vs 12 months, p = 0.028; median OS: not reached; p = 0.027). Multivariate analysis showed that ALDH1A1 was an independent favorable prognostic factor for DFS (p = 0.032, HR: 0.438, 95% CI: 0.206–0.932) and OS (p = 0.025, HR: 0.279, 95% CI: 0.091–0.852) in LCNEC patients. CONCLUSION: This study suggests that ALDH1A1 can act as a favorable independent prognostic factor for LCNEC, which related to the epithelioid phenotype in EMT, and its internal mechanism needs further study. Neoplasia Press 2022-02-23 /pmc/articles/PMC8881670/ /pubmed/35219092 http://dx.doi.org/10.1016/j.tranon.2022.101379 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Commentary Zhang, Jinyao Sun, Xujie Liu, Li Dong, Jiyan Deng, Lei Wang, Xin Guo, Yiying Ying, Jianming Xing, Puyuan Li, Junling Yang, Lin Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title | Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title_full | Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title_fullStr | Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title_full_unstemmed | Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title_short | Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma |
title_sort | clinical significance of aldh1a1 expression and its association with e-cadherin and n-cadherin in resected large cell neuroendocrine carcinoma |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881670/ https://www.ncbi.nlm.nih.gov/pubmed/35219092 http://dx.doi.org/10.1016/j.tranon.2022.101379 |
work_keys_str_mv | AT zhangjinyao clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT sunxujie clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT liuli clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT dongjiyan clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT denglei clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT wangxin clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT guoyiying clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT yingjianming clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT xingpuyuan clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT lijunling clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma AT yanglin clinicalsignificanceofaldh1a1expressionanditsassociationwithecadherinandncadherininresectedlargecellneuroendocrinecarcinoma |