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Genetic overlap between temporomandibular disorders and primary headaches: A systematic review

Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review,...

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Detalles Bibliográficos
Autores principales: Cruz, Diogo, Monteiro, Francisca, Paço, Maria, Vaz-Silva, Manuel, Lemos, Carolina, Alves-Ferreira, Miguel, Pinho, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881721/
https://www.ncbi.nlm.nih.gov/pubmed/35242249
http://dx.doi.org/10.1016/j.jdsr.2022.02.002
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author Cruz, Diogo
Monteiro, Francisca
Paço, Maria
Vaz-Silva, Manuel
Lemos, Carolina
Alves-Ferreira, Miguel
Pinho, Teresa
author_facet Cruz, Diogo
Monteiro, Francisca
Paço, Maria
Vaz-Silva, Manuel
Lemos, Carolina
Alves-Ferreira, Miguel
Pinho, Teresa
author_sort Cruz, Diogo
collection PubMed
description Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were COMT, MTHFR, and ESR1. COMT was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of MTHFR gene regulation on either TMD or PHD was found. The most robust results are concerning the ESR1 gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of ESR1 and COMT genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.
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spelling pubmed-88817212022-03-02 Genetic overlap between temporomandibular disorders and primary headaches: A systematic review Cruz, Diogo Monteiro, Francisca Paço, Maria Vaz-Silva, Manuel Lemos, Carolina Alves-Ferreira, Miguel Pinho, Teresa Jpn Dent Sci Rev Review Article Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were COMT, MTHFR, and ESR1. COMT was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of MTHFR gene regulation on either TMD or PHD was found. The most robust results are concerning the ESR1 gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of ESR1 and COMT genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies. Elsevier 2022-11 2022-02-23 /pmc/articles/PMC8881721/ /pubmed/35242249 http://dx.doi.org/10.1016/j.jdsr.2022.02.002 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Cruz, Diogo
Monteiro, Francisca
Paço, Maria
Vaz-Silva, Manuel
Lemos, Carolina
Alves-Ferreira, Miguel
Pinho, Teresa
Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title_full Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title_fullStr Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title_full_unstemmed Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title_short Genetic overlap between temporomandibular disorders and primary headaches: A systematic review
title_sort genetic overlap between temporomandibular disorders and primary headaches: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881721/
https://www.ncbi.nlm.nih.gov/pubmed/35242249
http://dx.doi.org/10.1016/j.jdsr.2022.02.002
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