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Prediction of drug–drug interaction potential mediated by transporters between dasatinib and metformin, pravastatin, and rosuvastatin using physiologically based pharmacokinetic modeling

PURPOSE: Recent in vitro studies demonstrated that dasatinib inhibits organic cation transporter 2 (OCT2), multidrug and toxin extrusion proteins (MATEs), and organic anion transporting polypeptide 1B1/1B3 (OATP1B1/1B3). We developed a physiologically based pharmacokinetic (PBPK) model to assess dru...

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Detalles Bibliográficos
Autores principales:	Chang, Ming, Bathena, Sai, Christopher, Lisa J., Shen, Hong, Roy, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882081/ https://www.ncbi.nlm.nih.gov/pubmed/35147740 http://dx.doi.org/10.1007/s00280-021-04394-z

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