Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might be involved in SCZ/ASD pathogenesis,...

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Detalles Bibliográficos
Autores principales: Wang, Chenyao, Horigane, Shin-ichiro, Wakamori, Minoru, Ueda, Shuhei, Kawabata, Takeshi, Fujii, Hajime, Kushima, Itaru, Kimura, Hiroki, Ishizuka, Kanako, Nakamura, Yukako, Iwayama, Yoshimi, Ikeda, Masashi, Iwata, Nakao, Okada, Takashi, Aleksic, Branko, Mori, Daisuke, Yoshida, Takashi, Bito, Haruhiko, Yoshikawa, Takeo, Takemoto-Kimura, Sayaka, Ozaki, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882172/
https://www.ncbi.nlm.nih.gov/pubmed/35220405
http://dx.doi.org/10.1038/s41398-022-01851-y

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