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CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma

Ewing sarcoma is the second most common bone malignancy in children and adolescents. In recent years, a large body of evidence has emerged that suggests Ewing tumors harbor large amounts of replication stress (RS). CDC7, also known as DDK (DBF4-dependent kinase), is a serine/threonine kinase that is...

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Detalles Bibliográficos
Autores principales:	Martin, Jeffrey C., Sims, Jennie R., Gupta, Ajay, Hagoel, Tamara J., Gao, Lingqiu, Lynch, Miranda L., Woloszynska, Anna, Melendy, Thomas, Kane, Jeremy F., Kuechle, Joseph, Ohm, Joyce E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882187/ https://www.ncbi.nlm.nih.gov/pubmed/35220396 http://dx.doi.org/10.1038/s41420-022-00877-x

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