Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem – evaluated by microdialysis in a porcine model: should patients with open fractures have higher doses of antibiotics?

AIMS: Prompt and sufficient broad-spectrum empirical antibiotic treatment is key to preventing infection following open tibial fractures. Succeeding co-administration, we dynamically assessed the time for which vancomycin and meropenem concentrations were above relevant epidemiological cut-off (ECOF...

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Detalles Bibliográficos
Autores principales: Vittrup, Sofus Ørbæk, Hanberg, Pelle, Knudsen, Martin Bruun, Tøstesen, Sara Kousgaard, Kipp, Josephine Olsen, Hansen, Jakob, Jørgensen, Nis Pedersen, Stilling, Maiken, Bue, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2022
Materias:
Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882321/
https://www.ncbi.nlm.nih.gov/pubmed/35176868
http://dx.doi.org/10.1302/2046-3758.112.BJR-2021-0321.R1

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