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Total and partial knee arthroplasty implants that maintain native load transfer in the tibia

AIMS: Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This st...

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Autores principales: Munford, Maxwell J., Stoddart, Jennifer C., Liddle, Alexander D., Cobb, Justin P., Jeffers, Jonathan R. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882327/
https://www.ncbi.nlm.nih.gov/pubmed/35168367
http://dx.doi.org/10.1302/2046-3758.112.BJR-2021-0304.R1
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author Munford, Maxwell J.
Stoddart, Jennifer C.
Liddle, Alexander D.
Cobb, Justin P.
Jeffers, Jonathan R. T.
author_facet Munford, Maxwell J.
Stoddart, Jennifer C.
Liddle, Alexander D.
Cobb, Justin P.
Jeffers, Jonathan R. T.
author_sort Munford, Maxwell J.
collection PubMed
description AIMS: Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This study investigates whether titanium lattice UKA and TKA implants can maintain natural load transfer in the proximal tibia. METHODS: In a cadaveric model, UKA and TKA procedures were performed on eight fresh-frozen knee specimens, using conventional (solid) and titanium lattice tibial implants. Stress at the bone-implant interfaces were measured and compared to the native knee. RESULTS: Titanium lattice implants were able to restore the mechanical environment of the native tibia for both UKA and TKA designs. Maximum stress at the bone-implant interface ranged from 1.2 MPa to 3.3 MPa compared with 1.3 MPa to 2.7 MPa for the native tibia. The conventional solid UKA and TKA implants reduced the maximum stress in the bone by a factor of 10 and caused > 70% of bone surface area to be underloaded compared to the native tibia. CONCLUSION: Titanium lattice implants maintained the natural mechanical loading in the proximal tibia after UKA and TKA, but conventional solid implants did not. This is an exciting first step towards implants that maintain bone health, but such implants also have to meet fatigue and micromotion criteria to be clinically viable. Cite this article: Bone Joint Res 2022;11(2):91–101.
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spelling pubmed-88823272022-03-17 Total and partial knee arthroplasty implants that maintain native load transfer in the tibia Munford, Maxwell J. Stoddart, Jennifer C. Liddle, Alexander D. Cobb, Justin P. Jeffers, Jonathan R. T. Bone Joint Res Knee AIMS: Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This study investigates whether titanium lattice UKA and TKA implants can maintain natural load transfer in the proximal tibia. METHODS: In a cadaveric model, UKA and TKA procedures were performed on eight fresh-frozen knee specimens, using conventional (solid) and titanium lattice tibial implants. Stress at the bone-implant interfaces were measured and compared to the native knee. RESULTS: Titanium lattice implants were able to restore the mechanical environment of the native tibia for both UKA and TKA designs. Maximum stress at the bone-implant interface ranged from 1.2 MPa to 3.3 MPa compared with 1.3 MPa to 2.7 MPa for the native tibia. The conventional solid UKA and TKA implants reduced the maximum stress in the bone by a factor of 10 and caused > 70% of bone surface area to be underloaded compared to the native tibia. CONCLUSION: Titanium lattice implants maintained the natural mechanical loading in the proximal tibia after UKA and TKA, but conventional solid implants did not. This is an exciting first step towards implants that maintain bone health, but such implants also have to meet fatigue and micromotion criteria to be clinically viable. Cite this article: Bone Joint Res 2022;11(2):91–101. The British Editorial Society of Bone & Joint Surgery 2022-02-16 /pmc/articles/PMC8882327/ /pubmed/35168367 http://dx.doi.org/10.1302/2046-3758.112.BJR-2021-0304.R1 Text en © 2022 Author(s) et al. https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attributions (CC BY 4.0) licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original author and source are credited.
spellingShingle Knee
Munford, Maxwell J.
Stoddart, Jennifer C.
Liddle, Alexander D.
Cobb, Justin P.
Jeffers, Jonathan R. T.
Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title_full Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title_fullStr Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title_full_unstemmed Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title_short Total and partial knee arthroplasty implants that maintain native load transfer in the tibia
title_sort total and partial knee arthroplasty implants that maintain native load transfer in the tibia
topic Knee
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882327/
https://www.ncbi.nlm.nih.gov/pubmed/35168367
http://dx.doi.org/10.1302/2046-3758.112.BJR-2021-0304.R1
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