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WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations
While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has de...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882397/ https://www.ncbi.nlm.nih.gov/pubmed/35248422 http://dx.doi.org/10.1016/j.vaccine.2022.02.038 |
| _version_ | 1784659687483899904 |
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| author | Singh, Jerome Amir Kochhar, Sonali Wolff, Jonathan Atuire, Caesar Bhan, Anant Emanuel, Ezekiel Faden, Ruth Ghimire, Prakash Greco, Dirceu Ho, Calvin Moon, Suerie Shamsi-Gooshki, Ehsan Touré, Aissatou Thomé, Beatriz Smith, Maxwell J. Upshur, Ross E.G. |
| author_facet | Singh, Jerome Amir Kochhar, Sonali Wolff, Jonathan Atuire, Caesar Bhan, Anant Emanuel, Ezekiel Faden, Ruth Ghimire, Prakash Greco, Dirceu Ho, Calvin Moon, Suerie Shamsi-Gooshki, Ehsan Touré, Aissatou Thomé, Beatriz Smith, Maxwell J. Upshur, Ross E.G. |
| author_sort | Singh, Jerome Amir |
| collection | PubMed |
| description | While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines. |
| format | Online Article Text |
| id | pubmed-8882397 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88823972022-02-28 WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations Singh, Jerome Amir Kochhar, Sonali Wolff, Jonathan Atuire, Caesar Bhan, Anant Emanuel, Ezekiel Faden, Ruth Ghimire, Prakash Greco, Dirceu Ho, Calvin Moon, Suerie Shamsi-Gooshki, Ehsan Touré, Aissatou Thomé, Beatriz Smith, Maxwell J. Upshur, Ross E.G. Vaccine Review While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines. Elsevier Science 2022-03-25 /pmc/articles/PMC8882397/ /pubmed/35248422 http://dx.doi.org/10.1016/j.vaccine.2022.02.038 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| spellingShingle | Review Singh, Jerome Amir Kochhar, Sonali Wolff, Jonathan Atuire, Caesar Bhan, Anant Emanuel, Ezekiel Faden, Ruth Ghimire, Prakash Greco, Dirceu Ho, Calvin Moon, Suerie Shamsi-Gooshki, Ehsan Touré, Aissatou Thomé, Beatriz Smith, Maxwell J. Upshur, Ross E.G. WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title | WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title_full | WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title_fullStr | WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title_full_unstemmed | WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title_short | WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations |
| title_sort | who guidance on covid-19 vaccine trial designs in the context of authorized covid-19 vaccines and expanding global access: ethical considerations |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882397/ https://www.ncbi.nlm.nih.gov/pubmed/35248422 http://dx.doi.org/10.1016/j.vaccine.2022.02.038 |
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