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SARS-CoV-2 vaccination washes away original antigenic sin
According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882427/ https://www.ncbi.nlm.nih.gov/pubmed/35272935 http://dx.doi.org/10.1016/j.it.2022.02.009 |
| _version_ | 1784659695695298560 |
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| author | Pillai, Shiv |
| author_facet | Pillai, Shiv |
| author_sort | Pillai, Shiv |
| collection | PubMed |
| description | According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as ‘original antigenic sin’, and this results in limited immunological breadth. |
| format | Online Article Text |
| id | pubmed-8882427 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88824272022-02-28 SARS-CoV-2 vaccination washes away original antigenic sin Pillai, Shiv Trends Immunol Spotlight According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as ‘original antigenic sin’, and this results in limited immunological breadth. Elsevier Ltd. 2022-04 2022-02-28 /pmc/articles/PMC8882427/ /pubmed/35272935 http://dx.doi.org/10.1016/j.it.2022.02.009 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Spotlight Pillai, Shiv SARS-CoV-2 vaccination washes away original antigenic sin |
| title | SARS-CoV-2 vaccination washes away original antigenic sin |
| title_full | SARS-CoV-2 vaccination washes away original antigenic sin |
| title_fullStr | SARS-CoV-2 vaccination washes away original antigenic sin |
| title_full_unstemmed | SARS-CoV-2 vaccination washes away original antigenic sin |
| title_short | SARS-CoV-2 vaccination washes away original antigenic sin |
| title_sort | sars-cov-2 vaccination washes away original antigenic sin |
| topic | Spotlight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882427/ https://www.ncbi.nlm.nih.gov/pubmed/35272935 http://dx.doi.org/10.1016/j.it.2022.02.009 |
| work_keys_str_mv | AT pillaishiv sarscov2vaccinationwashesawayoriginalantigenicsin |