A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank of human patient-derived xenografts (PDXs) and matched organoid cultures from tumors that represent the greatest unmet need: endocrine-resistant, treatment-refract...

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Detalles Bibliográficos
Autores principales: Guillen, Katrin P., Fujita, Maihi, Butterfield, Andrew J., Scherer, Sandra D., Bailey, Matthew H., Chu, Zhengtao, DeRose, Yoko S., Zhao, Ling, Cortes-Sanchez, Emilio, Yang, Chieh-Hsiang, Toner, Jennifer, Wang, Guoying, Qiao, Yi, Huang, Xiaomeng, Greenland, Jeffery A., Vahrenkamp, Jeffery M., Lum, David H., Factor, Rachel E., Nelson, Edward W., Matsen, Cindy B., Poretta, Jane M., Rosenthal, Regina, Beck, Anna C., Buys, Saundra S., Vaklavas, Christos, Ward, John H., Jensen, Randy L., Jones, Kevin B., Li, Zheqi, Oesterreich, Steffi, Dobrolecki, Lacey E., Pathi, Satya S., Woo, Xing Yi, Berrett, Kristofer C., Wadsworth, Mark E., Chuang, Jeffrey H., Lewis, Michael T., Marth, Gabor T., Gertz, Jason, Varley, Katherine E., Welm, Bryan E., Welm, Alana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882468/
https://www.ncbi.nlm.nih.gov/pubmed/35221336
http://dx.doi.org/10.1038/s43018-022-00337-6

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