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Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease

Topoisomerase1 (TOP1)-mediated chromosomal breaks are endogenous sources of DNA damage that affect neuronal genome stability. Whether TOP1 DNA breaks are sources of genomic instability in Huntington’s disease (HD) is unknown. Here, we report defective 53BP1 recruitment in multiple HD cell models, in...

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Detalles Bibliográficos
Autores principales:	Palminha, Nelma M., Dos Santos Souza, Cleide, Griffin, Jon, Liao, Chunyan, Ferraiuolo, Laura, El-Khamisy, Sherif F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882575/ https://www.ncbi.nlm.nih.gov/pubmed/35224690 http://dx.doi.org/10.1007/s00018-022-04204-6

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