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A Novel System for Measuring Pterygium's Progress Using Deep Learning

Pterygium is a common ocular surface disease. When pterygium significantly invades the cornea, it limits eye movement and impairs vision, which requires surgery to remove. It is medically recognized that when the width of the pterygium that invades the cornea is >3 mm, the patient can be treated...

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Autores principales: Wan, Cheng, Shao, Yiwei, Wang, Chenghu, Jing, Jiaona, Yang, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882585/
https://www.ncbi.nlm.nih.gov/pubmed/35237630
http://dx.doi.org/10.3389/fmed.2022.819971
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author Wan, Cheng
Shao, Yiwei
Wang, Chenghu
Jing, Jiaona
Yang, Weihua
author_facet Wan, Cheng
Shao, Yiwei
Wang, Chenghu
Jing, Jiaona
Yang, Weihua
author_sort Wan, Cheng
collection PubMed
description Pterygium is a common ocular surface disease. When pterygium significantly invades the cornea, it limits eye movement and impairs vision, which requires surgery to remove. It is medically recognized that when the width of the pterygium that invades the cornea is >3 mm, the patient can be treated with surgical resection. Owing to this, this study proposes a system for diagnosing and measuring the pathological progress of pterygium using deep learning methods, which aims to assist doctors in designing pterygium surgical treatment strategies. The proposed system only needs to input the anterior segment images of patients to automatically and efficiently measure the width of the pterygium that invades the cornea, and the patient's pterygium symptom status can be obtained. The system consists of three modules, including cornea segmentation module, pterygium segmentation module, and measurement module. Both segmentation modules use convolutional neural networks. In the pterygium segmentation module, to adapt the diversity of the pterygium's shape and size, an improved U-Net++ model by adding an Attention gate before each up-sampling layer is proposed. The Attention gates extract information related to the target, so that the model can pay more attention to the shape and size of the pterygium. The measurement module realizes the measurement of the width and area of the pterygium that invades the cornea and the classification of pterygium symptom status. In this study, the effectiveness of the proposed system is verified using datasets collected from the ocular surface diseases center at the Affiliated Eye Hospital of Nanjing Medical University. The results obtained show that the Dice coefficient of the cornea segmentation module and the pterygium segmentation module are 0.9620 and 0.9020, respectively. The Kappa consistency coefficient between the final measurement results of the system and the doctor's visual inspection results is 0.918, which proves that the system has practical application significance.
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spelling pubmed-88825852022-03-01 A Novel System for Measuring Pterygium's Progress Using Deep Learning Wan, Cheng Shao, Yiwei Wang, Chenghu Jing, Jiaona Yang, Weihua Front Med (Lausanne) Medicine Pterygium is a common ocular surface disease. When pterygium significantly invades the cornea, it limits eye movement and impairs vision, which requires surgery to remove. It is medically recognized that when the width of the pterygium that invades the cornea is >3 mm, the patient can be treated with surgical resection. Owing to this, this study proposes a system for diagnosing and measuring the pathological progress of pterygium using deep learning methods, which aims to assist doctors in designing pterygium surgical treatment strategies. The proposed system only needs to input the anterior segment images of patients to automatically and efficiently measure the width of the pterygium that invades the cornea, and the patient's pterygium symptom status can be obtained. The system consists of three modules, including cornea segmentation module, pterygium segmentation module, and measurement module. Both segmentation modules use convolutional neural networks. In the pterygium segmentation module, to adapt the diversity of the pterygium's shape and size, an improved U-Net++ model by adding an Attention gate before each up-sampling layer is proposed. The Attention gates extract information related to the target, so that the model can pay more attention to the shape and size of the pterygium. The measurement module realizes the measurement of the width and area of the pterygium that invades the cornea and the classification of pterygium symptom status. In this study, the effectiveness of the proposed system is verified using datasets collected from the ocular surface diseases center at the Affiliated Eye Hospital of Nanjing Medical University. The results obtained show that the Dice coefficient of the cornea segmentation module and the pterygium segmentation module are 0.9620 and 0.9020, respectively. The Kappa consistency coefficient between the final measurement results of the system and the doctor's visual inspection results is 0.918, which proves that the system has practical application significance. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882585/ /pubmed/35237630 http://dx.doi.org/10.3389/fmed.2022.819971 Text en Copyright © 2022 Wan, Shao, Wang, Jing and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wan, Cheng
Shao, Yiwei
Wang, Chenghu
Jing, Jiaona
Yang, Weihua
A Novel System for Measuring Pterygium's Progress Using Deep Learning
title A Novel System for Measuring Pterygium's Progress Using Deep Learning
title_full A Novel System for Measuring Pterygium's Progress Using Deep Learning
title_fullStr A Novel System for Measuring Pterygium's Progress Using Deep Learning
title_full_unstemmed A Novel System for Measuring Pterygium's Progress Using Deep Learning
title_short A Novel System for Measuring Pterygium's Progress Using Deep Learning
title_sort novel system for measuring pterygium's progress using deep learning
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882585/
https://www.ncbi.nlm.nih.gov/pubmed/35237630
http://dx.doi.org/10.3389/fmed.2022.819971
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