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Implications of Gut Microbiota in Neurodegenerative Diseases
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882587/ https://www.ncbi.nlm.nih.gov/pubmed/35237258 http://dx.doi.org/10.3389/fimmu.2022.785644 |
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author | Zhang, Haoming Chen, Yijia Wang, Zifan Xie, Gaijie Liu, Mingming Yuan, Boyu Chai, Hongxia Wang, Wei Cheng, Ping |
author_facet | Zhang, Haoming Chen, Yijia Wang, Zifan Xie, Gaijie Liu, Mingming Yuan, Boyu Chai, Hongxia Wang, Wei Cheng, Ping |
author_sort | Zhang, Haoming |
collection | PubMed |
description | The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases. |
format | Online Article Text |
id | pubmed-8882587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88825872022-03-01 Implications of Gut Microbiota in Neurodegenerative Diseases Zhang, Haoming Chen, Yijia Wang, Zifan Xie, Gaijie Liu, Mingming Yuan, Boyu Chai, Hongxia Wang, Wei Cheng, Ping Front Immunol Immunology The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882587/ /pubmed/35237258 http://dx.doi.org/10.3389/fimmu.2022.785644 Text en Copyright © 2022 Zhang, Chen, Wang, Xie, Liu, Yuan, Chai, Wang and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Haoming Chen, Yijia Wang, Zifan Xie, Gaijie Liu, Mingming Yuan, Boyu Chai, Hongxia Wang, Wei Cheng, Ping Implications of Gut Microbiota in Neurodegenerative Diseases |
title | Implications of Gut Microbiota in Neurodegenerative Diseases |
title_full | Implications of Gut Microbiota in Neurodegenerative Diseases |
title_fullStr | Implications of Gut Microbiota in Neurodegenerative Diseases |
title_full_unstemmed | Implications of Gut Microbiota in Neurodegenerative Diseases |
title_short | Implications of Gut Microbiota in Neurodegenerative Diseases |
title_sort | implications of gut microbiota in neurodegenerative diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882587/ https://www.ncbi.nlm.nih.gov/pubmed/35237258 http://dx.doi.org/10.3389/fimmu.2022.785644 |
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