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Implications of Gut Microbiota in Neurodegenerative Diseases

The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), w...

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Autores principales: Zhang, Haoming, Chen, Yijia, Wang, Zifan, Xie, Gaijie, Liu, Mingming, Yuan, Boyu, Chai, Hongxia, Wang, Wei, Cheng, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882587/
https://www.ncbi.nlm.nih.gov/pubmed/35237258
http://dx.doi.org/10.3389/fimmu.2022.785644
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author Zhang, Haoming
Chen, Yijia
Wang, Zifan
Xie, Gaijie
Liu, Mingming
Yuan, Boyu
Chai, Hongxia
Wang, Wei
Cheng, Ping
author_facet Zhang, Haoming
Chen, Yijia
Wang, Zifan
Xie, Gaijie
Liu, Mingming
Yuan, Boyu
Chai, Hongxia
Wang, Wei
Cheng, Ping
author_sort Zhang, Haoming
collection PubMed
description The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases.
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spelling pubmed-88825872022-03-01 Implications of Gut Microbiota in Neurodegenerative Diseases Zhang, Haoming Chen, Yijia Wang, Zifan Xie, Gaijie Liu, Mingming Yuan, Boyu Chai, Hongxia Wang, Wei Cheng, Ping Front Immunol Immunology The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882587/ /pubmed/35237258 http://dx.doi.org/10.3389/fimmu.2022.785644 Text en Copyright © 2022 Zhang, Chen, Wang, Xie, Liu, Yuan, Chai, Wang and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Haoming
Chen, Yijia
Wang, Zifan
Xie, Gaijie
Liu, Mingming
Yuan, Boyu
Chai, Hongxia
Wang, Wei
Cheng, Ping
Implications of Gut Microbiota in Neurodegenerative Diseases
title Implications of Gut Microbiota in Neurodegenerative Diseases
title_full Implications of Gut Microbiota in Neurodegenerative Diseases
title_fullStr Implications of Gut Microbiota in Neurodegenerative Diseases
title_full_unstemmed Implications of Gut Microbiota in Neurodegenerative Diseases
title_short Implications of Gut Microbiota in Neurodegenerative Diseases
title_sort implications of gut microbiota in neurodegenerative diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882587/
https://www.ncbi.nlm.nih.gov/pubmed/35237258
http://dx.doi.org/10.3389/fimmu.2022.785644
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