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Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain

Previous observational studies have suggested an important role of omega-3 in low back pain. In the present study, we used a two-sample Mendelian randomization (MR) study to identify the putative causal link between omega-3 and low back pain. A broadly used genome-wide association study (GWAS) (n =...

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Autores principales: Zhou, Shan, Zhu, Gaizhi, Xu, Yaqi, Gao, Ran, Li, Huan, Han, Gencheng, Su, Wenting, Wang, Renxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882682/
https://www.ncbi.nlm.nih.gov/pubmed/35237642
http://dx.doi.org/10.3389/fnut.2022.819635
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author Zhou, Shan
Zhu, Gaizhi
Xu, Yaqi
Gao, Ran
Li, Huan
Han, Gencheng
Su, Wenting
Wang, Renxi
author_facet Zhou, Shan
Zhu, Gaizhi
Xu, Yaqi
Gao, Ran
Li, Huan
Han, Gencheng
Su, Wenting
Wang, Renxi
author_sort Zhou, Shan
collection PubMed
description Previous observational studies have suggested an important role of omega-3 in low back pain. In the present study, we used a two-sample Mendelian randomization (MR) study to identify the putative causal link between omega-3 and low back pain. A broadly used genome-wide association study (GWAS) (n = 8,866 individuals from European ancestry) was used to select plasma omega-3 genetic instrumental variables (IVs). A previously reported GWAS (4,863 cases and 74,589 controls from European ancestry) for low back pain were used to assess the effect of plasma omega-3 levels on low back pain. MR-egger_intercept, MR-PRESSO, MR_egger, and inverse variance weighted (IVW) in Cochran's Q-test were used to determine the pleiotropy and heterogeneity, respectively. MR-egger, weighted median, IVW, and weighted mode were used to perform MR analysis. Finally, the effect of a single nucleotide polymorphism (SNP) was used to test the SNP bias. We did not find a significant pleiotropy or heterogeneity of all six selected plasma omega-3 genetic IVs in low back pain GWAS. Expectedly, we found that as plasma omega-3 levels genetically increased, the risk of low back pain had a decreased trend using MR-egger (Beta = −0.593, p = 0.228; OR = 0.553) and weighted mode (Beta = −0.251, p = 0.281; OR = 0.778). This reduced trend was further proven by weighted median (Beta = −0.436, p = 0.025; OR = 0.646) and IVW (Beta = −0.366, p = 0.049; OR = 0.694). Our analysis suggested a putative causal link between genetically increased plasma omega-3 levels and the reduced risk of low back pain in European ancestries. Thus, the supplementation of omega-3 may be important for the prevention and treatment of low back pain.
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spelling pubmed-88826822022-03-01 Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain Zhou, Shan Zhu, Gaizhi Xu, Yaqi Gao, Ran Li, Huan Han, Gencheng Su, Wenting Wang, Renxi Front Nutr Nutrition Previous observational studies have suggested an important role of omega-3 in low back pain. In the present study, we used a two-sample Mendelian randomization (MR) study to identify the putative causal link between omega-3 and low back pain. A broadly used genome-wide association study (GWAS) (n = 8,866 individuals from European ancestry) was used to select plasma omega-3 genetic instrumental variables (IVs). A previously reported GWAS (4,863 cases and 74,589 controls from European ancestry) for low back pain were used to assess the effect of plasma omega-3 levels on low back pain. MR-egger_intercept, MR-PRESSO, MR_egger, and inverse variance weighted (IVW) in Cochran's Q-test were used to determine the pleiotropy and heterogeneity, respectively. MR-egger, weighted median, IVW, and weighted mode were used to perform MR analysis. Finally, the effect of a single nucleotide polymorphism (SNP) was used to test the SNP bias. We did not find a significant pleiotropy or heterogeneity of all six selected plasma omega-3 genetic IVs in low back pain GWAS. Expectedly, we found that as plasma omega-3 levels genetically increased, the risk of low back pain had a decreased trend using MR-egger (Beta = −0.593, p = 0.228; OR = 0.553) and weighted mode (Beta = −0.251, p = 0.281; OR = 0.778). This reduced trend was further proven by weighted median (Beta = −0.436, p = 0.025; OR = 0.646) and IVW (Beta = −0.366, p = 0.049; OR = 0.694). Our analysis suggested a putative causal link between genetically increased plasma omega-3 levels and the reduced risk of low back pain in European ancestries. Thus, the supplementation of omega-3 may be important for the prevention and treatment of low back pain. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882682/ /pubmed/35237642 http://dx.doi.org/10.3389/fnut.2022.819635 Text en Copyright © 2022 Zhou, Zhu, Xu, Gao, Li, Han, Su and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhou, Shan
Zhu, Gaizhi
Xu, Yaqi
Gao, Ran
Li, Huan
Han, Gencheng
Su, Wenting
Wang, Renxi
Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title_full Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title_fullStr Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title_full_unstemmed Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title_short Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain
title_sort mendelian randomization study on the putative causal effects of omega-3 fatty acids on low back pain
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882682/
https://www.ncbi.nlm.nih.gov/pubmed/35237642
http://dx.doi.org/10.3389/fnut.2022.819635
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