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Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications

Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common clinical use. Reasons for this include high cost...

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Autores principales: Nicksic, Peter J., Donnelly, D’Andrea T., Hesse, Madison, Bedi, Simran, Verma, Nishant, Seitz, Allison J., Shoffstall, Andrew J., Ludwig, Kip A., Dingle, Aaron M., Poore, Samuel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882968/
https://www.ncbi.nlm.nih.gov/pubmed/35237571
http://dx.doi.org/10.3389/fbioe.2022.793945
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author Nicksic, Peter J.
Donnelly, D’Andrea T.
Hesse, Madison
Bedi, Simran
Verma, Nishant
Seitz, Allison J.
Shoffstall, Andrew J.
Ludwig, Kip A.
Dingle, Aaron M.
Poore, Samuel O.
author_facet Nicksic, Peter J.
Donnelly, D’Andrea T.
Hesse, Madison
Bedi, Simran
Verma, Nishant
Seitz, Allison J.
Shoffstall, Andrew J.
Ludwig, Kip A.
Dingle, Aaron M.
Poore, Samuel O.
author_sort Nicksic, Peter J.
collection PubMed
description Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common clinical use. Reasons for this include high cost and lack of faith in the efficacy of bone growth stimulators on behalf of clinicians. The purpose of this narrative review is to examine the preclinical body of literature supporting electrical stimulation and its effect on bone properties and elucidate gaps in clinical translation with an emphasis on device specifications and mechanisms of action. When examining these studies, trends become apparent. In vitro and small animal studies are successful in inducing osteogenesis with all electrical stimulation modalities: direct current, pulsed electromagnetic field, and capacitive coupling. However, large animal studies are largely unsuccessful with the non-invasive modalities. This may be due to issues of scale and thickness of tissue planes with varying levels of resistivity, not present in small animal models. Additionally, it is difficult to draw conclusions from studies due to the varying units of stimulation strength and stimulation protocols and incomplete device specification reporting. To better understand the disconnect between the large and small animal model, the authors recommend increasing scientific rigor for these studies and reporting a novel minimum set of parameters depending on the stimulation modality.
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spelling pubmed-88829682022-03-01 Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications Nicksic, Peter J. Donnelly, D’Andrea T. Hesse, Madison Bedi, Simran Verma, Nishant Seitz, Allison J. Shoffstall, Andrew J. Ludwig, Kip A. Dingle, Aaron M. Poore, Samuel O. Front Bioeng Biotechnol Bioengineering and Biotechnology Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common clinical use. Reasons for this include high cost and lack of faith in the efficacy of bone growth stimulators on behalf of clinicians. The purpose of this narrative review is to examine the preclinical body of literature supporting electrical stimulation and its effect on bone properties and elucidate gaps in clinical translation with an emphasis on device specifications and mechanisms of action. When examining these studies, trends become apparent. In vitro and small animal studies are successful in inducing osteogenesis with all electrical stimulation modalities: direct current, pulsed electromagnetic field, and capacitive coupling. However, large animal studies are largely unsuccessful with the non-invasive modalities. This may be due to issues of scale and thickness of tissue planes with varying levels of resistivity, not present in small animal models. Additionally, it is difficult to draw conclusions from studies due to the varying units of stimulation strength and stimulation protocols and incomplete device specification reporting. To better understand the disconnect between the large and small animal model, the authors recommend increasing scientific rigor for these studies and reporting a novel minimum set of parameters depending on the stimulation modality. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882968/ /pubmed/35237571 http://dx.doi.org/10.3389/fbioe.2022.793945 Text en Copyright © 2022 Nicksic, Donnelly, Hesse, Bedi, Verma, Seitz, Shoffstall, Ludwig, Dingle and Poore. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Nicksic, Peter J.
Donnelly, D’Andrea T.
Hesse, Madison
Bedi, Simran
Verma, Nishant
Seitz, Allison J.
Shoffstall, Andrew J.
Ludwig, Kip A.
Dingle, Aaron M.
Poore, Samuel O.
Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title_full Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title_fullStr Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title_full_unstemmed Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title_short Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications
title_sort electronic bone growth stimulators for augmentation of osteogenesis in in vitro and in vivo models: a narrative review of electrical stimulation mechanisms and device specifications
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882968/
https://www.ncbi.nlm.nih.gov/pubmed/35237571
http://dx.doi.org/10.3389/fbioe.2022.793945
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