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Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases

The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structural features of ATP synthase were first resolved nea...

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Autores principales: Ebanks, Brad, Chakrabarti, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882969/
https://www.ncbi.nlm.nih.gov/pubmed/35237666
http://dx.doi.org/10.3389/fmolb.2022.854321
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author Ebanks, Brad
Chakrabarti, Lisa
author_facet Ebanks, Brad
Chakrabarti, Lisa
author_sort Ebanks, Brad
collection PubMed
description The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structural features of ATP synthase were first resolved nearly three decades ago, significant progress has been made in understanding its role in health and disease. Mitochondrial dysfunction is common to neurodegeneration, with elevated oxidative stress a hallmark of this dysfunction. The patterns of this oxidative stress, including molecular targets and the form of oxidative modification, can vary widely. In this mini review we discuss the oxidative modifications of ATP synthase that have been observed in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Oxidative modifications of ATP synthase in Alzheimer’s disease are well-documented, and there is a growing body of knowledge on the subject in Parkinson’s disease. The consideration of ATP synthase as a pharmacological target in a variety of diseases underlines the importance of understanding these modifications, both as a potential target, and also as inhibitors of any pharmacological intervention.
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spelling pubmed-88829692022-03-01 Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases Ebanks, Brad Chakrabarti, Lisa Front Mol Biosci Molecular Biosciences The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structural features of ATP synthase were first resolved nearly three decades ago, significant progress has been made in understanding its role in health and disease. Mitochondrial dysfunction is common to neurodegeneration, with elevated oxidative stress a hallmark of this dysfunction. The patterns of this oxidative stress, including molecular targets and the form of oxidative modification, can vary widely. In this mini review we discuss the oxidative modifications of ATP synthase that have been observed in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Oxidative modifications of ATP synthase in Alzheimer’s disease are well-documented, and there is a growing body of knowledge on the subject in Parkinson’s disease. The consideration of ATP synthase as a pharmacological target in a variety of diseases underlines the importance of understanding these modifications, both as a potential target, and also as inhibitors of any pharmacological intervention. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8882969/ /pubmed/35237666 http://dx.doi.org/10.3389/fmolb.2022.854321 Text en Copyright © 2022 Ebanks and Chakrabarti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Ebanks, Brad
Chakrabarti, Lisa
Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title_full Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title_fullStr Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title_full_unstemmed Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title_short Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
title_sort mitochondrial atp synthase is a target of oxidative stress in neurodegenerative diseases
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882969/
https://www.ncbi.nlm.nih.gov/pubmed/35237666
http://dx.doi.org/10.3389/fmolb.2022.854321
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