Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma

Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also di...

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Autores principales: Mondello, Patrizia, Ansell, Stephen M., Nowakowski, Grzegorz S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883034/
https://www.ncbi.nlm.nih.gov/pubmed/35237302
http://dx.doi.org/10.3389/fgene.2022.826594
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author Mondello, Patrizia
Ansell, Stephen M.
Nowakowski, Grzegorz S.
author_facet Mondello, Patrizia
Ansell, Stephen M.
Nowakowski, Grzegorz S.
author_sort Mondello, Patrizia
collection PubMed
description Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also discuss precision therapy strategies to reverse their aberrant signaling by targeting mutated proteins or counterbalance epigenetic mechanisms.
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spelling pubmed-88830342022-03-01 Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma Mondello, Patrizia Ansell, Stephen M. Nowakowski, Grzegorz S. Front Genet Genetics Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also discuss precision therapy strategies to reverse their aberrant signaling by targeting mutated proteins or counterbalance epigenetic mechanisms. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8883034/ /pubmed/35237302 http://dx.doi.org/10.3389/fgene.2022.826594 Text en Copyright © 2022 Mondello, Ansell and Nowakowski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Mondello, Patrizia
Ansell, Stephen M.
Nowakowski, Grzegorz S.
Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title_full Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title_fullStr Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title_full_unstemmed Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title_short Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
title_sort immune epigenetic crosstalk between malignant b cells and the tumor microenvironment in b cell lymphoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883034/
https://www.ncbi.nlm.nih.gov/pubmed/35237302
http://dx.doi.org/10.3389/fgene.2022.826594
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