PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling

Doxorubicin (Dox) is a chemotherapeutic drug used to treat a wide range of cancers, but its clinical application is limited due to its cardiotoxicity. Protein kinase C-ζ (PKC-ζ) is a serine/threonine kinase belonging to atypical protein kinase C (PKC) subfamily, and is activated by its phosphorylati...

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Detalles Bibliográficos
Autores principales: Cao, Yan-Jun, Li, Jing-Yan, Wang, Pan-Xia, Lin, Zhi-Rong, Yu, Wen-Jing, Zhang, Ji-Guo, Lu, Jing, Liu, Pei-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883055/
https://www.ncbi.nlm.nih.gov/pubmed/35237161
http://dx.doi.org/10.3389/fphar.2022.798436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883055/
https://www.ncbi.nlm.nih.gov/pubmed/35237161
http://dx.doi.org/10.3389/fphar.2022.798436

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