Cargando…

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

BACKGROUND: The composition of the tumor immune microenvironment (TIME) associated with good prognosis generally also predicts the success of immunotherapy, and both entail the presence of pre-existing tumor-specific T cells. Here, the blueprint of the TIME associated with such an ongoing tumor-spec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdulrahman, Ziena, Santegoets, Saskia J, Sturm, Gregor, Charoentong, Pornpimol, Ijsselsteijn, Marieke E, Somarakis, Antonios, Höllt, Thomas, Finotello, Francesca, Trajanoski, Zlatko, van Egmond, Sylvia L, Mustafa, Dana A M, Welters, Marij J P, de Miranda, Noel F C C, van der Burg, Sjoerd H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883276/ https://www.ncbi.nlm.nih.gov/pubmed/35217577 http://dx.doi.org/10.1136/jitc-2021-004346

Ejemplares similares

NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division
por: Borst, Linda, et al.
Publicado: (2021)

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors
por: Duurland, Chantal L, et al.
Publicado: (2022)

TIminer: NGS data mining pipeline for cancer immunology and immunotherapy
por: Tappeiner, Elias, et al.
Publicado: (2017)

Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy
por: Kortekaas, Kim E, et al.
Publicado: (2021)

Detection and functional assessment of regulatory T cells in clinical samples
por: Santegoets, Saskia, et al.
Publicado: (2014)

Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
por: van Elsas, Marit J, et al.
Publicado: (2023)

The Tumor Microenvironment and Immunotherapy of Oropharyngeal Squamous Cell Carcinoma
por: Welters, Marij J. P., et al.
Publicado: (2020)

EGFR signaling suppresses type 1 cytokine-induced T-cell attracting chemokine secretion in head and neck cancer
por: Ma, Wenbo, et al.
Publicado: (2018)

CD163(+) cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer
por: Santegoets, Saskia J, et al.
Publicado: (2020)

Monitoring of the Immune Dysfunction in Cancer Patients
por: Santegoets, Saskia J. A. M., et al.
Publicado: (2016)

The combined HPV16-E2/E6/E7 T cell response in oropharyngeal cancer predicts superior survival
por: Santegoets, Saskia J., et al.
Publicado: (2023)

Mathematical models for translational and clinical oncology
por: Gallasch, Ralf, et al.
Publicado: (2013)

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
por: Efremova, Mirjana, et al.
Publicado: (2018)

Bioinformatics for cancer immunology and immunotherapy
por: Charoentong, Pornpimol, et al.
Publicado: (2012)

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data
por: Ijsselsteijn, Marieke E., et al.
Publicado: (2021)

New strategies for cancer immunotherapy: targeting regulatory T cells
por: Finotello, Francesca, et al.
Publicado: (2017)

Quantifying tumor-infiltrating immune cells from transcriptomics data
por: Finotello, Francesca, et al.
Publicado: (2018)

The colorectal cancer immune paradox revisited
por: Angelova, Mihaela, et al.
Publicado: (2015)

A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy
por: Abdulrahman, Ziena, et al.
Publicado: (2020)

Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction
por: Mlecnik, Bernhard, et al.
Publicado: (2010)

High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status
por: Kortekaas, Kim E., et al.
Publicado: (2019)

Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data
por: Sturm, Gregor, et al.
Publicado: (2020)

Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination
por: Abdulrahman, Ziena, et al.
Publicado: (2020)

The pan-cancer landscape of abnormal DNA methylation and intratumor microorganisms
por: Zhou, Ping, et al.
Publicado: (2023)

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
por: Bindea, Gabriela, et al.
Publicado: (2009)

Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy
por: Efremova, Mirjana, et al.
Publicado: (2017)

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy
por: Beyranvand Nejad, Elham, et al.
Publicado: (2020)

Capillary Leukocytes, Microaggregates, and the Response to Hypoxemia in the Microcirculation of Coronavirus Disease 2019 Patients
por: Favaron, Emanuele, et al.
Publicado: (2021)

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden
por: van den Bulk, Jitske, et al.
Publicado: (2023)

Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells
por: Danielsson, Brooke E., et al.
Publicado: (2020)

dK-Microaggregation: Anonymizing Graphs with Differential Privacy Guarantees
por: Iftikhar, Masooma, et al.
Publicado: (2020)

Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses
por: Santegoets, S. J., et al.
Publicado: (2019)

NeoFuse: predicting fusion neoantigens from RNA sequencing data
por: Fotakis, Georgios, et al.
Publicado: (2020)

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer
por: Tymoszuk, Piotr, et al.
Publicado: (2014)

The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer
por: Santegoets, Saskia J., et al.
Publicado: (2022)

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
por: Angelova, Mihaela, et al.
Publicado: (2015)

Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals
por: Pieterse, Elmar, et al.
Publicado: (2016)

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S
por: Harryvan, Tom J, et al.
Publicado: (2022)

Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
por: Finotello, Francesca, et al.
Publicado: (2019)

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
por: Finotello, Francesca, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bdljv4geh440osskr22uo0j5bh