Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient

Background: MOG antibody associated demyelinating disease (MOGAD) is a newly described autoimmune disorder that presents with monophasic or multiphasic demyelination in children. Case: We report a case of MOGAD that was refractory to current treatment algorithms and required rapid escalation of immu...

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Detalles Bibliográficos
Autores principales: Kroenke, Eve, Ankar, Alex, Malani Shukla, Nikita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883298/
https://www.ncbi.nlm.nih.gov/pubmed/35237705
http://dx.doi.org/10.1177/2329048X221079093
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author Kroenke, Eve
Ankar, Alex
Malani Shukla, Nikita
author_facet Kroenke, Eve
Ankar, Alex
Malani Shukla, Nikita
author_sort Kroenke, Eve
collection PubMed
description Background: MOG antibody associated demyelinating disease (MOGAD) is a newly described autoimmune disorder that presents with monophasic or multiphasic demyelination in children. Case: We report a case of MOGAD that was refractory to current treatment algorithms and required rapid escalation of immunotherapy to achieve disease control. Conclusion: This case helps to further expand the phenotype of MOGAD and emphasizes the need to consider MOGAD in patients presenting with focal neurologic deficits, altered mental status, and/or seizures.
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spelling pubmed-88832982022-03-01 Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient Kroenke, Eve Ankar, Alex Malani Shukla, Nikita Child Neurol Open Case Report Background: MOG antibody associated demyelinating disease (MOGAD) is a newly described autoimmune disorder that presents with monophasic or multiphasic demyelination in children. Case: We report a case of MOGAD that was refractory to current treatment algorithms and required rapid escalation of immunotherapy to achieve disease control. Conclusion: This case helps to further expand the phenotype of MOGAD and emphasizes the need to consider MOGAD in patients presenting with focal neurologic deficits, altered mental status, and/or seizures. SAGE Publications 2022-02-25 /pmc/articles/PMC8883298/ /pubmed/35237705 http://dx.doi.org/10.1177/2329048X221079093 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Kroenke, Eve
Ankar, Alex
Malani Shukla, Nikita
Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title_full Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title_fullStr Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title_full_unstemmed Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title_short Refractory MOG-Associated Demyelinating Disease in a Pediatric Patient
title_sort refractory mog-associated demyelinating disease in a pediatric patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883298/
https://www.ncbi.nlm.nih.gov/pubmed/35237705
http://dx.doi.org/10.1177/2329048X221079093
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