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Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans

Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, whi...

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Autores principales: Antuña, Eduardo, Carlos Bermejo-Millo, Juan, Caso-Onzain, Enrique, Caso-Peláez, Enrique, Potes, Yaiza, Coto-Montes, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883322/
https://www.ncbi.nlm.nih.gov/pubmed/35237574
http://dx.doi.org/10.3389/fbioe.2022.800011
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author Antuña, Eduardo
Carlos Bermejo-Millo, Juan
Caso-Onzain, Enrique
Caso-Peláez, Enrique
Potes, Yaiza
Coto-Montes, Ana
author_facet Antuña, Eduardo
Carlos Bermejo-Millo, Juan
Caso-Onzain, Enrique
Caso-Peláez, Enrique
Potes, Yaiza
Coto-Montes, Ana
author_sort Antuña, Eduardo
collection PubMed
description Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery.
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spelling pubmed-88833222022-03-01 Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans Antuña, Eduardo Carlos Bermejo-Millo, Juan Caso-Onzain, Enrique Caso-Peláez, Enrique Potes, Yaiza Coto-Montes, Ana Front Bioeng Biotechnol Bioengineering and Biotechnology Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8883322/ /pubmed/35237574 http://dx.doi.org/10.3389/fbioe.2022.800011 Text en Copyright © 2022 Antuña, Carlos Bermejo-Millo, Caso-Onzain, Caso-Peláez, Potes and Coto-Montes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Antuña, Eduardo
Carlos Bermejo-Millo, Juan
Caso-Onzain, Enrique
Caso-Peláez, Enrique
Potes, Yaiza
Coto-Montes, Ana
Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title_full Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title_fullStr Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title_full_unstemmed Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title_short Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
title_sort removal of environmental nanoparticles increases protein synthesis and energy production in healthy humans
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883322/
https://www.ncbi.nlm.nih.gov/pubmed/35237574
http://dx.doi.org/10.3389/fbioe.2022.800011
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