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Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data

The goal of the present study was to assess the predictive performance of a minimal generic rat physiologically based kinetic (PBK) model based on in vitro and in silico input data to predict peak plasma concentrations (C(max)) upon single oral dosing. To this purpose, a dataset was generated of 396...

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Detalles Bibliográficos
Autores principales:	Punt, Ans, Louisse, Jochem, Pinckaers, Nicole, Fabian, Eric, van Ravenzwaay, Bennard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Biotransformation, Toxicokinetics, and Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883350/ https://www.ncbi.nlm.nih.gov/pubmed/34927682 http://dx.doi.org/10.1093/toxsci/kfab150

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