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Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis

There is little information about the outcomes of pediatric patients with hepatolithiasis after living donor liver transplantation (LDLT). We retrospectively reviewed hepatolithiasis after pediatric LDLT. Between May 2001 and December 2020, 310 pediatric patients underwent LDLT with hepaticojejunost...

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Autores principales: Sanada, Yukihiro, Sakuma, Yasunaru, Onishi, Yasuharu, Okada, Noriki, Hirata, Yuta, Horiuchi, Toshio, Omameuda, Takahiko, Lefor, Alan Kawarai, Sata, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883429/
https://www.ncbi.nlm.nih.gov/pubmed/35237098
http://dx.doi.org/10.3389/ti.2022.10220
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author Sanada, Yukihiro
Sakuma, Yasunaru
Onishi, Yasuharu
Okada, Noriki
Hirata, Yuta
Horiuchi, Toshio
Omameuda, Takahiko
Lefor, Alan Kawarai
Sata, Naohiro
author_facet Sanada, Yukihiro
Sakuma, Yasunaru
Onishi, Yasuharu
Okada, Noriki
Hirata, Yuta
Horiuchi, Toshio
Omameuda, Takahiko
Lefor, Alan Kawarai
Sata, Naohiro
author_sort Sanada, Yukihiro
collection PubMed
description There is little information about the outcomes of pediatric patients with hepatolithiasis after living donor liver transplantation (LDLT). We retrospectively reviewed hepatolithiasis after pediatric LDLT. Between May 2001 and December 2020, 310 pediatric patients underwent LDLT with hepaticojejunostomy. Treatment for 57 patients (18%) with post-transplant biliary strictures included interventions through double-balloon enteroscopy (DBE) in 100 times, percutaneous transhepatic biliary drainage (PTBD) in 43, surgical re-anastomosis in 4, and repeat liver transplantation in 3. The median age and interval at treatment were 12.3 years old and 2.4 years after LDLT, respectively. At the time of treatments, 23 patients (7%) had developed hepatolithiasis of whom 12 (52%) were diagnosed by computed tomography before treatment. Treatment for hepatolithiasis included intervention through DBE performed 34 times and PTBD 6, including lithotripsy by catheter 23 times, removal of plastic stent in 8, natural exclusion after balloon dilatation in 7, and impossibility of removal in 2. The incidence of recurrent hepatolithiasis was 30%. The 15-years graft survival rates in patients with and without hepatolithiasis were 91% and 89%, respectively (p = 0.860). Although hepatolithiasis after pediatric LDLT can be treated using interventions through DBE or PTBD and its long-term prognosis is good, the recurrence rate is somewhat high.
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spelling pubmed-88834292022-03-01 Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis Sanada, Yukihiro Sakuma, Yasunaru Onishi, Yasuharu Okada, Noriki Hirata, Yuta Horiuchi, Toshio Omameuda, Takahiko Lefor, Alan Kawarai Sata, Naohiro Transpl Int Health Archive There is little information about the outcomes of pediatric patients with hepatolithiasis after living donor liver transplantation (LDLT). We retrospectively reviewed hepatolithiasis after pediatric LDLT. Between May 2001 and December 2020, 310 pediatric patients underwent LDLT with hepaticojejunostomy. Treatment for 57 patients (18%) with post-transplant biliary strictures included interventions through double-balloon enteroscopy (DBE) in 100 times, percutaneous transhepatic biliary drainage (PTBD) in 43, surgical re-anastomosis in 4, and repeat liver transplantation in 3. The median age and interval at treatment were 12.3 years old and 2.4 years after LDLT, respectively. At the time of treatments, 23 patients (7%) had developed hepatolithiasis of whom 12 (52%) were diagnosed by computed tomography before treatment. Treatment for hepatolithiasis included intervention through DBE performed 34 times and PTBD 6, including lithotripsy by catheter 23 times, removal of plastic stent in 8, natural exclusion after balloon dilatation in 7, and impossibility of removal in 2. The incidence of recurrent hepatolithiasis was 30%. The 15-years graft survival rates in patients with and without hepatolithiasis were 91% and 89%, respectively (p = 0.860). Although hepatolithiasis after pediatric LDLT can be treated using interventions through DBE or PTBD and its long-term prognosis is good, the recurrence rate is somewhat high. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8883429/ /pubmed/35237098 http://dx.doi.org/10.3389/ti.2022.10220 Text en Copyright © 2022 Sanada, Sakuma, Onishi, Okada, Hirata, Horiuchi, Omameuda, Lefor and Sata. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Sanada, Yukihiro
Sakuma, Yasunaru
Onishi, Yasuharu
Okada, Noriki
Hirata, Yuta
Horiuchi, Toshio
Omameuda, Takahiko
Lefor, Alan Kawarai
Sata, Naohiro
Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title_full Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title_fullStr Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title_full_unstemmed Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title_short Hepatolithiasis After Living Donor Liver Transplantation in Pediatric Patients: Mechanism, Diagnosis, Treatment, and Prognosis
title_sort hepatolithiasis after living donor liver transplantation in pediatric patients: mechanism, diagnosis, treatment, and prognosis
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883429/
https://www.ncbi.nlm.nih.gov/pubmed/35237098
http://dx.doi.org/10.3389/ti.2022.10220
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