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Human topoisomerases and their roles in genome stability and organization

Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) topoisomerases. In this Review, we discuss their biochemistry and their roles in transcription, DNA replication and chromatin rem...

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Detalles Bibliográficos
Autores principales:	Pommier, Yves, Nussenzweig, André, Takeda, Shunichi, Austin, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883456/ https://www.ncbi.nlm.nih.gov/pubmed/35228717 http://dx.doi.org/10.1038/s41580-022-00452-3

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