Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense

Three new polyketide dimers named huoshanmycins A‒C (1–3) were isolated from a plant endophytic Streptomyces sp. HS-3-L-1 in the leaf of Dendrobium huoshanense, which was collected from the Cultivation base in Jiuxianzun Huoshanshihu Co., Ltd. The dimeric structures of huoshanmycins were composed of...

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Autores principales: Zhu, Youjuan, Kong, Yichao, Hong, Yu, Zhang, Ling, Li, Simin, Hou, Shurong, Chen, Xiabin, Xie, Tian, Hu, Yang, Wang, Xiachang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883461/
https://www.ncbi.nlm.nih.gov/pubmed/35237566
http://dx.doi.org/10.3389/fchem.2021.807508
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author Zhu, Youjuan
Kong, Yichao
Hong, Yu
Zhang, Ling
Li, Simin
Hou, Shurong
Chen, Xiabin
Xie, Tian
Hu, Yang
Wang, Xiachang
author_facet Zhu, Youjuan
Kong, Yichao
Hong, Yu
Zhang, Ling
Li, Simin
Hou, Shurong
Chen, Xiabin
Xie, Tian
Hu, Yang
Wang, Xiachang
author_sort Zhu, Youjuan
collection PubMed
description Three new polyketide dimers named huoshanmycins A‒C (1–3) were isolated from a plant endophytic Streptomyces sp. HS-3-L-1 in the leaf of Dendrobium huoshanense, which was collected from the Cultivation base in Jiuxianzun Huoshanshihu Co., Ltd. The dimeric structures of huoshanmycins were composed of unusual polyketides SEK43, SEK15, or UWM4, with a unique methylene linkage. Their structures were elucidated through comprehensive 1D-/2D-NMR and HRESIMS spectroscopic data analysis. The cytotoxicity against MV4-11 human leukemia cell by the Cell Counting Kit-8 (CCK8) method was evaluated using isolated compounds with triptolide as positive control (IC(50): 1.1 ± 0.4 μM). Huoshanmycins A and B (1, 2) displayed moderate cytotoxicity with IC(50) values of 32.9 ± 7.2 and 33.2 ± 6.1 μM, respectively.
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spelling pubmed-88834612022-03-01 Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense Zhu, Youjuan Kong, Yichao Hong, Yu Zhang, Ling Li, Simin Hou, Shurong Chen, Xiabin Xie, Tian Hu, Yang Wang, Xiachang Front Chem Chemistry Three new polyketide dimers named huoshanmycins A‒C (1–3) were isolated from a plant endophytic Streptomyces sp. HS-3-L-1 in the leaf of Dendrobium huoshanense, which was collected from the Cultivation base in Jiuxianzun Huoshanshihu Co., Ltd. The dimeric structures of huoshanmycins were composed of unusual polyketides SEK43, SEK15, or UWM4, with a unique methylene linkage. Their structures were elucidated through comprehensive 1D-/2D-NMR and HRESIMS spectroscopic data analysis. The cytotoxicity against MV4-11 human leukemia cell by the Cell Counting Kit-8 (CCK8) method was evaluated using isolated compounds with triptolide as positive control (IC(50): 1.1 ± 0.4 μM). Huoshanmycins A and B (1, 2) displayed moderate cytotoxicity with IC(50) values of 32.9 ± 7.2 and 33.2 ± 6.1 μM, respectively. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8883461/ /pubmed/35237566 http://dx.doi.org/10.3389/fchem.2021.807508 Text en Copyright © 2022 Zhu, Kong, Hong, Zhang, Li, Hou, Chen, Xie, Hu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Zhu, Youjuan
Kong, Yichao
Hong, Yu
Zhang, Ling
Li, Simin
Hou, Shurong
Chen, Xiabin
Xie, Tian
Hu, Yang
Wang, Xiachang
Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title_full Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title_fullStr Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title_full_unstemmed Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title_short Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense
title_sort huoshanmycins a‒c, new polyketide dimers produced by endophytic streptomyces sp. hs-3-l-1 from dendrobium huoshanense
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883461/
https://www.ncbi.nlm.nih.gov/pubmed/35237566
http://dx.doi.org/10.3389/fchem.2021.807508
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