γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet

[Image: see text] The blood levels of microRNA-122 (miR-122) is associated with the severity of cardiovascular disorders, and targeting it with efficient and safer miR inhibitors could be a promising approach. Here, we report the generation of a γ-peptide nucleic acid (γPNA)-based miR-122 inhibitor...

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Detalles Bibliográficos
Autores principales: Gaddam, Ravinder Reddy, Dhuri, Karishma, Kim, Young-Rae, Jacobs, Julia S., Kumar, Vikas, Li, Qiuxia, Irani, Kaikobad, Bahal, Raman, Vikram, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883473/
https://www.ncbi.nlm.nih.gov/pubmed/35133835
http://dx.doi.org/10.1021/acs.jmedchem.1c01831

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