Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation

The ability of the cellular immune system to discriminate self from foreign antigens depends on the appropriate calibration of the T cell receptor (TCR) signalling threshold. The lymphocyte homeostatic cytokine interleukin 7 (IL-7) is known to affect TCR thresholding, but the molecular mechanism is...

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Detalles Bibliográficos
Autores principales: Queiroz, Rayner M. L., Piper, Siân C., Rees, Johanna S., Strickson, Sam, Briend, Emmanuel, Low, Choon Pei, Ferguson, G. John, Lilley, Kathryn S., Jackson, Antony P., Finch, Donna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Immunology & Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883493/
https://www.ncbi.nlm.nih.gov/pubmed/35015072
http://dx.doi.org/10.1042/BCJ20210313

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