Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human heart failure, whether BRAF promotes cardiomyocyte hyp...

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Detalles Bibliográficos
Autores principales: Clerk, Angela, Meijles, Daniel N., Hardyman, Michelle A., Fuller, Stephen J., Chothani, Sonia P., Cull, Joshua J., Cooper, Susanna T.E., Alharbi, Hajed O., Vanezis, Konstantinos, Felkin, Leanne E., Markou, Thomais, Leonard, Samuel J., Shaw, Spencer W., Rackham, Owen J.L., Cook, Stuart A., Glennon, Peter E., Sheppard, Mary N., Sembrat, John C., Rojas, Mauricio, McTiernan, Charles F., Barton, Paul J., Sugden, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cardiovascular System & Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883496/
https://www.ncbi.nlm.nih.gov/pubmed/35147166
http://dx.doi.org/10.1042/BCJ20210615

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