ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells

Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the role of this splice factor in RNA splicing and hema...

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Detalles Bibliográficos
Autores principales: Madan, Vikas, Cao, Zeya, Teoh, Weoi Woon, Dakle, Pushkar, Han, Lin, Shyamsunder, Pavithra, Jeitany, Maya, Zhou, Siqin, Li, Jia, Mohd Nordin, Hazimah Binte, Shi, Jizhong, Yu, Shuizhou, Yang, Henry, Hossain, Md Zakir, Chng, Wee Joo, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883539/
https://www.ncbi.nlm.nih.gov/pubmed/33691379
http://dx.doi.org/10.3324/haematol.2020.260562

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