Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences physiological plasma VWF clearance. MGL inhibition was...

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Detalles Bibliográficos
Autores principales: Ward, Soracha E., O’Sullivan, Jamie M., Moran, Alan B., Spencer, Daniel I. R., Gardner, Richard A., Sharma, Jyotika, Fazavana, Judicael, Monopoli, Marco, McKinnon, Thomas A. J., Chion, Alain, Haberichter, Sandra, O’Donnell, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883566/
https://www.ncbi.nlm.nih.gov/pubmed/33763999
http://dx.doi.org/10.3324/haematol.2020.274720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883566/
https://www.ncbi.nlm.nih.gov/pubmed/33763999
http://dx.doi.org/10.3324/haematol.2020.274720

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