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New Insights Into the Function of Flavohemoglobin in Mycobacterium tuberculosis: Role as a NADPH-Dependent Disulfide Reductase and D-Lactate-Dependent Mycothione Reductase

Mycobacterium tuberculosis (Mtb) produces an unconventional flavohemoglobin (MtbFHb) that carries a FAD-binding site similar to D-lactate dehydrogenases (D-LDH) and oxidizes D-lactate into pyruvate. The molecular mechanism by which MtbFHb functions in Mtb remains unknown. We discovered that the D-LD...

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Detalles Bibliográficos
Autores principales:	Thakur, Naveen, Sharma, Amar Nath, Hade, Mangesh Dattu, Chhaya, Ajay, Kumar, Ashwani, Jolly, Ravinder Singh, Dikshit, Kanak L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883573/ https://www.ncbi.nlm.nih.gov/pubmed/35237528 http://dx.doi.org/10.3389/fcimb.2021.796727

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