ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

BACKGROUND: Dysfunctional p53 signaling is one of the major causes of hepatocellular carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 inactivation in HCC have not been fully clarified. The role of Krüppel-associated box (KRAB)-type zinc-finger protein ZNF498 in tumori...

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Detalles Bibliográficos
Autores principales: Zhang, Xiuyuan, Zheng, Qijian, Yue, Xiuying, Yuan, Zhanna, Ling, Jiming, Yuan, Yanzhi, Liang, Yanying, Sun, Aihua, Liu, Yuchen, Li, Hui, Xu, Kaikun, He, Fuchu, Wang, Jian, Wu, Jin, Zhao, Chunling, Tian, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883630/
https://www.ncbi.nlm.nih.gov/pubmed/35227287
http://dx.doi.org/10.1186/s13046-022-02288-3

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