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A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres

BACKGROUND: Cancer cells can proliferate indefinitely through telomere maintenance mechanisms. These mechanisms include telomerase-dependent elongation, mediated by TERT activation, and alternative lengthening of telomeres (ALT), linked to loss of ATRX or DAXX. METHODS: We analyzed the telomeric con...

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Detalles Bibliográficos
Autores principales:	Sharaf, Radwa, Montesion, Meagan, Hopkins, Julia F., Song, Jiarong, Frampton, Garrett M., Albacker, Lee A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883689/ https://www.ncbi.nlm.nih.gov/pubmed/35227290 http://dx.doi.org/10.1186/s13073-022-01029-7

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