Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy

Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these ma...

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Detalles Bibliográficos
Autores principales: Lee, Su Yeon, Loll, Emma Grace, Hassan, Abd-Elrahman Said, Cheng, Mingyu, Wang, Aijun, Farmer, Diana Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883961/
https://www.ncbi.nlm.nih.gov/pubmed/35225964
http://dx.doi.org/10.3390/jdb10010011
Descripción
Sumario:Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for lymphangiogenesis. Gene mutations and dysregulations implicated in pathogenesis of lymphatic malformations are discussed. Finally, we touch on current and developing therapies with special attention on targeted biotherapeutics.

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