Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy

Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these ma...

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Autores principales: Lee, Su Yeon, Loll, Emma Grace, Hassan, Abd-Elrahman Said, Cheng, Mingyu, Wang, Aijun, Farmer, Diana Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883961/
https://www.ncbi.nlm.nih.gov/pubmed/35225964
http://dx.doi.org/10.3390/jdb10010011
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author Lee, Su Yeon
Loll, Emma Grace
Hassan, Abd-Elrahman Said
Cheng, Mingyu
Wang, Aijun
Farmer, Diana Lee
author_facet Lee, Su Yeon
Loll, Emma Grace
Hassan, Abd-Elrahman Said
Cheng, Mingyu
Wang, Aijun
Farmer, Diana Lee
author_sort Lee, Su Yeon
collection PubMed
description Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for lymphangiogenesis. Gene mutations and dysregulations implicated in pathogenesis of lymphatic malformations are discussed. Finally, we touch on current and developing therapies with special attention on targeted biotherapeutics.
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spelling pubmed-88839612022-03-01 Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy Lee, Su Yeon Loll, Emma Grace Hassan, Abd-Elrahman Said Cheng, Mingyu Wang, Aijun Farmer, Diana Lee J Dev Biol Review Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for lymphangiogenesis. Gene mutations and dysregulations implicated in pathogenesis of lymphatic malformations are discussed. Finally, we touch on current and developing therapies with special attention on targeted biotherapeutics. MDPI 2022-02-08 /pmc/articles/PMC8883961/ /pubmed/35225964 http://dx.doi.org/10.3390/jdb10010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Su Yeon
Loll, Emma Grace
Hassan, Abd-Elrahman Said
Cheng, Mingyu
Wang, Aijun
Farmer, Diana Lee
Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title_full Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title_fullStr Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title_full_unstemmed Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title_short Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy
title_sort genetic and molecular determinants of lymphatic malformations: potential targets for therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883961/
https://www.ncbi.nlm.nih.gov/pubmed/35225964
http://dx.doi.org/10.3390/jdb10010011
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