Construction of a Humanized Artificial VHH Library Reproducing Structural Features of Camelid VHHs for Therapeutics

A variable domain of heavy chain antibody (VHH) has different binding properties than conventional antibodies. Conventional antibodies prefer binding to the convex portion of the antigen, whereas VHHs prefer epitopes, such as crevices and clefts on the antigen. Therefore, developing candidates with...

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Detalles Bibliográficos
Autores principales: Murakami, Taihei, Kumachi, Shigefumi, Matsunaga, Yasuhiro, Sato, Miwa, Wakabayashi-Nakao, Kanako, Masaki, Hidekazu, Yonehara, Ryo, Motohashi, Maiko, Nemoto, Naoto, Tsuchiya, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884020/
https://www.ncbi.nlm.nih.gov/pubmed/35225868
http://dx.doi.org/10.3390/antib11010010

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