RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2

BACKGROUND: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin‐2 (ATXN2) gene. The mutant ATXN2 protein with a polyglutamine tract is known to be toxic and contributes to the SCA2 pathogenesis. OBJECTIVE: Here, we tested the hypothesis t...

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Detalles Bibliográficos
Autores principales: Li, Pan P., Moulick, Roumita, Feng, Hongxuan, Sun, Xin, Arbez, Nicolas, Jin, Jing, Marque, Leonard O., Hedglen, Erin, Chan, H.Y. Edwin, Ross, Christopher A., Pulst, Stefan M., Margolis, Russell L., Woodson, Sarah, Rudnicki, Dobrila D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884117/
https://www.ncbi.nlm.nih.gov/pubmed/34390268
http://dx.doi.org/10.1002/mds.28729

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