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Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients
The relationship between pyroptosis-related long non-coding RNAs (pyroptosis-related lncRNAs) and glioma prognosis have not been studied clearly. Basing on The Cancer Genome Atlas and The Chinese Glioma Genome Atlas datasets, we firstly identified 23 pyroptosis-related lncRNAs with Pearson coefficie...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884250/ https://www.ncbi.nlm.nih.gov/pubmed/35237509 http://dx.doi.org/10.3389/fonc.2022.779168 |
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author | Tanzhu, Guilong Li, Na Li, Zhanzhan Zhou, Rongrong Shen, Liangfang |
author_facet | Tanzhu, Guilong Li, Na Li, Zhanzhan Zhou, Rongrong Shen, Liangfang |
author_sort | Tanzhu, Guilong |
collection | PubMed |
description | The relationship between pyroptosis-related long non-coding RNAs (pyroptosis-related lncRNAs) and glioma prognosis have not been studied clearly. Basing on The Cancer Genome Atlas and The Chinese Glioma Genome Atlas datasets, we firstly identified 23 pyroptosis-related lncRNAs with Pearson coefficient |r| > 0.5 and p < 0.001. The survival probability was lower in cluster 1. 13 lncRNAs was included into signature and divided all the glioma patients into two groups, among which survival probability of the high-risk group was lower than that in low-risk group (P<0.001). The risk score was higher in the age>60, dead grade 3, cluster 1 and immune score high groups. Furthermore, subgroup analysis showed patients with different grades, IDH and 1p19ql state distinguished by the median of risk score had different survival probability. Risk score was one of independent factors for glioma prognosis, and 1-, 3-, 5-years survival were calculated in nomogram. Meanwhile, the same as the median risk score in TCGA cohort, the glioma patients from CGGA were categorized into two groups and validated the outcome mentioned above(P<0.01). GO and KEGG analysis revealed the immunity process of the targeted genes. Thus, the immune filtration we compared showed naive B cell, resting dendritic cells, activated NK cells, activated Mast cells, monocytes are higher in low-risk group. Moreover, level of the activated NK cells, M0-and M1 Macrophages was in positive relationship with the risk score. Besides, competing endogenous RNA (ceRNA) network display interaction among microRNA, lncRNAs and their targeted genes. Pyroptosis-related lncRNAs could be a dependent prognosis factor and maybe linked to the immune response in glioma. This prognosis signature had potential value in estimate the survival of the patients with glioma. |
format | Online Article Text |
id | pubmed-8884250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88842502022-03-01 Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients Tanzhu, Guilong Li, Na Li, Zhanzhan Zhou, Rongrong Shen, Liangfang Front Oncol Oncology The relationship between pyroptosis-related long non-coding RNAs (pyroptosis-related lncRNAs) and glioma prognosis have not been studied clearly. Basing on The Cancer Genome Atlas and The Chinese Glioma Genome Atlas datasets, we firstly identified 23 pyroptosis-related lncRNAs with Pearson coefficient |r| > 0.5 and p < 0.001. The survival probability was lower in cluster 1. 13 lncRNAs was included into signature and divided all the glioma patients into two groups, among which survival probability of the high-risk group was lower than that in low-risk group (P<0.001). The risk score was higher in the age>60, dead grade 3, cluster 1 and immune score high groups. Furthermore, subgroup analysis showed patients with different grades, IDH and 1p19ql state distinguished by the median of risk score had different survival probability. Risk score was one of independent factors for glioma prognosis, and 1-, 3-, 5-years survival were calculated in nomogram. Meanwhile, the same as the median risk score in TCGA cohort, the glioma patients from CGGA were categorized into two groups and validated the outcome mentioned above(P<0.01). GO and KEGG analysis revealed the immunity process of the targeted genes. Thus, the immune filtration we compared showed naive B cell, resting dendritic cells, activated NK cells, activated Mast cells, monocytes are higher in low-risk group. Moreover, level of the activated NK cells, M0-and M1 Macrophages was in positive relationship with the risk score. Besides, competing endogenous RNA (ceRNA) network display interaction among microRNA, lncRNAs and their targeted genes. Pyroptosis-related lncRNAs could be a dependent prognosis factor and maybe linked to the immune response in glioma. This prognosis signature had potential value in estimate the survival of the patients with glioma. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8884250/ /pubmed/35237509 http://dx.doi.org/10.3389/fonc.2022.779168 Text en Copyright © 2022 Tanzhu, Li, Li, Zhou and Shen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Tanzhu, Guilong Li, Na Li, Zhanzhan Zhou, Rongrong Shen, Liangfang Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title | Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title_full | Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title_fullStr | Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title_full_unstemmed | Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title_short | Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients |
title_sort | molecular subtypes and prognostic signature of pyroptosis-related lncrnas in glioma patients |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884250/ https://www.ncbi.nlm.nih.gov/pubmed/35237509 http://dx.doi.org/10.3389/fonc.2022.779168 |
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