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The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome

BACKGROUND/OBJECTIVES: The present study aimed to validate the Italian version of the Hyperphagia Questionnaire (HQ), a 11-items questionnaire developed to assess hyperphagia in individuals with Prader-Willi syndrome (PWS). This is a complex neurodevelopmental disorder characterized by endocrine dys...

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Autores principales: Licenziati, Maria Rosaria, Bacchini, Dario, Crinò, Antonino, Grugni, Graziano, Fintini, Danilo, Osimani, Sara, Ragusa, Letizia, Sacco, Michele, Iughetti, Lorenzo, De Sanctis, Luisa, Franzese, Adriana, Wasniewska, Malgorzata Gabriela, Faienza, Maria Felicia, Delvecchio, Maurizio, Esposito, Concetta, Valerio, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884358/
https://www.ncbi.nlm.nih.gov/pubmed/35237541
http://dx.doi.org/10.3389/fped.2022.829486
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author Licenziati, Maria Rosaria
Bacchini, Dario
Crinò, Antonino
Grugni, Graziano
Fintini, Danilo
Osimani, Sara
Ragusa, Letizia
Sacco, Michele
Iughetti, Lorenzo
De Sanctis, Luisa
Franzese, Adriana
Wasniewska, Malgorzata Gabriela
Faienza, Maria Felicia
Delvecchio, Maurizio
Esposito, Concetta
Valerio, Giuliana
author_facet Licenziati, Maria Rosaria
Bacchini, Dario
Crinò, Antonino
Grugni, Graziano
Fintini, Danilo
Osimani, Sara
Ragusa, Letizia
Sacco, Michele
Iughetti, Lorenzo
De Sanctis, Luisa
Franzese, Adriana
Wasniewska, Malgorzata Gabriela
Faienza, Maria Felicia
Delvecchio, Maurizio
Esposito, Concetta
Valerio, Giuliana
author_sort Licenziati, Maria Rosaria
collection PubMed
description BACKGROUND/OBJECTIVES: The present study aimed to validate the Italian version of the Hyperphagia Questionnaire (HQ), a 11-items questionnaire developed to assess hyperphagia in individuals with Prader-Willi syndrome (PWS). This is a complex neurodevelopmental disorder characterized by endocrine dysfunction, hypotonia, intellectual disability, psychiatric disorders and obesity. METHODS: Parents of 219 individuals with PWS (age range 3–54 years; M(age) = 17.90; 108 Males), recruited in 12 hospitals in Italy responded to HQ during routine visits. In function of the level of analyses the sample was divided into two subgroups (<18> years) or into four age-subgroups (2.5–4.5; 4.5–8; 8–18; >18 years) corresponding to different clinical stages. RESULTS: Confirmatory factor analysis (CFA) confirmed the three hyperphagic subdimensions of the original structure (behavior, drive, and severity), but one item was dropped out, reducing the final version to 10 items. Using multi-group CFA, HQ showed satisfactory indexes of measurement invariance by age. Good indexes of internal consistency (Cronbach's alpha and McDonald's Omega coefficients) were found for each subdimension. The three hyperphagia subdimensions positively converged with other food-related measures: emotional overeating, food enjoyment, food responsiveness, and satiety responsiveness. A significant increase of all hyperphagic subdimensions was found across age groups. Higher hyperphagic levels were found in participants with higher body mass index. Hyperphagic drive differently increased in function of the interaction between age and underlying genetic mechanisms. CONCLUSION: The Italian version of the HQ is a psychometrically valid and reliable instrument for assessing hyperphagia in individuals with PWS. This tool may prove useful to evaluate the efficacy of pharmacologic and rehabilitative treatments.
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spelling pubmed-88843582022-03-01 The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome Licenziati, Maria Rosaria Bacchini, Dario Crinò, Antonino Grugni, Graziano Fintini, Danilo Osimani, Sara Ragusa, Letizia Sacco, Michele Iughetti, Lorenzo De Sanctis, Luisa Franzese, Adriana Wasniewska, Malgorzata Gabriela Faienza, Maria Felicia Delvecchio, Maurizio Esposito, Concetta Valerio, Giuliana Front Pediatr Pediatrics BACKGROUND/OBJECTIVES: The present study aimed to validate the Italian version of the Hyperphagia Questionnaire (HQ), a 11-items questionnaire developed to assess hyperphagia in individuals with Prader-Willi syndrome (PWS). This is a complex neurodevelopmental disorder characterized by endocrine dysfunction, hypotonia, intellectual disability, psychiatric disorders and obesity. METHODS: Parents of 219 individuals with PWS (age range 3–54 years; M(age) = 17.90; 108 Males), recruited in 12 hospitals in Italy responded to HQ during routine visits. In function of the level of analyses the sample was divided into two subgroups (<18> years) or into four age-subgroups (2.5–4.5; 4.5–8; 8–18; >18 years) corresponding to different clinical stages. RESULTS: Confirmatory factor analysis (CFA) confirmed the three hyperphagic subdimensions of the original structure (behavior, drive, and severity), but one item was dropped out, reducing the final version to 10 items. Using multi-group CFA, HQ showed satisfactory indexes of measurement invariance by age. Good indexes of internal consistency (Cronbach's alpha and McDonald's Omega coefficients) were found for each subdimension. The three hyperphagia subdimensions positively converged with other food-related measures: emotional overeating, food enjoyment, food responsiveness, and satiety responsiveness. A significant increase of all hyperphagic subdimensions was found across age groups. Higher hyperphagic levels were found in participants with higher body mass index. Hyperphagic drive differently increased in function of the interaction between age and underlying genetic mechanisms. CONCLUSION: The Italian version of the HQ is a psychometrically valid and reliable instrument for assessing hyperphagia in individuals with PWS. This tool may prove useful to evaluate the efficacy of pharmacologic and rehabilitative treatments. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8884358/ /pubmed/35237541 http://dx.doi.org/10.3389/fped.2022.829486 Text en Copyright © 2022 Licenziati, Bacchini, Crinò, Grugni, Fintini, Osimani, Ragusa, Sacco, Iughetti, De Sanctis, Franzese, Wasniewska, Faienza, Delvecchio, Esposito and Valerio. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Licenziati, Maria Rosaria
Bacchini, Dario
Crinò, Antonino
Grugni, Graziano
Fintini, Danilo
Osimani, Sara
Ragusa, Letizia
Sacco, Michele
Iughetti, Lorenzo
De Sanctis, Luisa
Franzese, Adriana
Wasniewska, Malgorzata Gabriela
Faienza, Maria Felicia
Delvecchio, Maurizio
Esposito, Concetta
Valerio, Giuliana
The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title_full The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title_fullStr The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title_full_unstemmed The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title_short The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome
title_sort hyperphagia questionnaire: insights from a multicentric validation study in individuals with prader willi syndrome
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884358/
https://www.ncbi.nlm.nih.gov/pubmed/35237541
http://dx.doi.org/10.3389/fped.2022.829486
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