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Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies

This study aims to obtain scientific evidence on the use of Citrus to control dyslipidemia. The surveys were carried out in 2020 and updated in March 2021, in the PubMed, Scopus, LILACS, and SciELO databases, using the following descriptors: Citrus, dyslipidemias, hypercholesterolemia, hyperlipidemi...

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Autores principales: Carvalho, Betina M. R., Nascimento, Laranda C., Nascimento, Jessica C., Gonçalves, Vitória S. dos S., Ziegelmann, Patricia K., Tavares, Débora S., Guimarães, Adriana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884359/
https://www.ncbi.nlm.nih.gov/pubmed/35237168
http://dx.doi.org/10.3389/fphar.2022.822678
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author Carvalho, Betina M. R.
Nascimento, Laranda C.
Nascimento, Jessica C.
Gonçalves, Vitória S. dos S.
Ziegelmann, Patricia K.
Tavares, Débora S.
Guimarães, Adriana G.
author_facet Carvalho, Betina M. R.
Nascimento, Laranda C.
Nascimento, Jessica C.
Gonçalves, Vitória S. dos S.
Ziegelmann, Patricia K.
Tavares, Débora S.
Guimarães, Adriana G.
author_sort Carvalho, Betina M. R.
collection PubMed
description This study aims to obtain scientific evidence on the use of Citrus to control dyslipidemia. The surveys were carried out in 2020 and updated in March 2021, in the PubMed, Scopus, LILACS, and SciELO databases, using the following descriptors: Citrus, dyslipidemias, hypercholesterolemia, hyperlipidemias, lipoproteins, and cholesterol. The risk of bias was assessed according to the Cochrane methodology for clinical trials and ARRIVE for preclinical trials. A meta-analysis was performed using the application of R software. A total of 958 articles were identified and 26 studies demonstrating the effectiveness of the Citrus genus in controlling dyslipidemia were selected, of which 25 were included in the meta-analysis. The effects of Citrus products on dyslipidemia appear consistently robust, acting to reduce total cholesterol, LDL, and triglycerides, in addition to increasing HDL. These effects are associated with the composition of the extracts, extremely rich in antioxidant, as flavonoids, and that act on biochemical targets involved in lipogenesis and beta-oxidation. The risk of bias over all of the included studies was considered critically low to moderate. The meta-analysis demonstrated results favorable to control dyslipidemia by Citrus products. On the other hand, high heterogeneity values were identified, weakening the evidence presented. From this study, one can suggest that Citrus species extracts are potential candidates for dyslipidemia control, but more studies are needed to increase the strength of this occurrence.
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spelling pubmed-88843592022-03-01 Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies Carvalho, Betina M. R. Nascimento, Laranda C. Nascimento, Jessica C. Gonçalves, Vitória S. dos S. Ziegelmann, Patricia K. Tavares, Débora S. Guimarães, Adriana G. Front Pharmacol Pharmacology This study aims to obtain scientific evidence on the use of Citrus to control dyslipidemia. The surveys were carried out in 2020 and updated in March 2021, in the PubMed, Scopus, LILACS, and SciELO databases, using the following descriptors: Citrus, dyslipidemias, hypercholesterolemia, hyperlipidemias, lipoproteins, and cholesterol. The risk of bias was assessed according to the Cochrane methodology for clinical trials and ARRIVE for preclinical trials. A meta-analysis was performed using the application of R software. A total of 958 articles were identified and 26 studies demonstrating the effectiveness of the Citrus genus in controlling dyslipidemia were selected, of which 25 were included in the meta-analysis. The effects of Citrus products on dyslipidemia appear consistently robust, acting to reduce total cholesterol, LDL, and triglycerides, in addition to increasing HDL. These effects are associated with the composition of the extracts, extremely rich in antioxidant, as flavonoids, and that act on biochemical targets involved in lipogenesis and beta-oxidation. The risk of bias over all of the included studies was considered critically low to moderate. The meta-analysis demonstrated results favorable to control dyslipidemia by Citrus products. On the other hand, high heterogeneity values were identified, weakening the evidence presented. From this study, one can suggest that Citrus species extracts are potential candidates for dyslipidemia control, but more studies are needed to increase the strength of this occurrence. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8884359/ /pubmed/35237168 http://dx.doi.org/10.3389/fphar.2022.822678 Text en Copyright © 2022 Carvalho, Nascimento, Nascimento, Gonçalves, Ziegelmann, Tavares and Guimarães. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Carvalho, Betina M. R.
Nascimento, Laranda C.
Nascimento, Jessica C.
Gonçalves, Vitória S. dos S.
Ziegelmann, Patricia K.
Tavares, Débora S.
Guimarães, Adriana G.
Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title_full Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title_fullStr Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title_full_unstemmed Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title_short Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies
title_sort citrus extract as a perspective for the control of dyslipidemia: a systematic review with meta-analysis from animal models to human studies
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884359/
https://www.ncbi.nlm.nih.gov/pubmed/35237168
http://dx.doi.org/10.3389/fphar.2022.822678
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