Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders

Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion cha...

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Detalles Bibliográficos
Autores principales: Bando, Yuki, Ishibashi, Masaru, Yamagishi, Satoru, Fukuda, Atsuo, Sato, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884360/
https://www.ncbi.nlm.nih.gov/pubmed/35237124
http://dx.doi.org/10.3389/fnins.2022.827284
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author Bando, Yuki
Ishibashi, Masaru
Yamagishi, Satoru
Fukuda, Atsuo
Sato, Kohji
author_facet Bando, Yuki
Ishibashi, Masaru
Yamagishi, Satoru
Fukuda, Atsuo
Sato, Kohji
author_sort Bando, Yuki
collection PubMed
description Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion channels and transporters in neocortical development. Next, we discuss links between neurological disorders caused by dysfunction of ion channels (channelopathies) and neocortical development. Finally, we introduce emerging optical techniques with potential applications in physiological studies of neocortical development and the pathophysiology of channelopathies.
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spelling pubmed-88843602022-03-01 Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders Bando, Yuki Ishibashi, Masaru Yamagishi, Satoru Fukuda, Atsuo Sato, Kohji Front Neurosci Neuroscience Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion channels and transporters in neocortical development. Next, we discuss links between neurological disorders caused by dysfunction of ion channels (channelopathies) and neocortical development. Finally, we introduce emerging optical techniques with potential applications in physiological studies of neocortical development and the pathophysiology of channelopathies. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8884360/ /pubmed/35237124 http://dx.doi.org/10.3389/fnins.2022.827284 Text en Copyright © 2022 Bando, Ishibashi, Yamagishi, Fukuda and Sato. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bando, Yuki
Ishibashi, Masaru
Yamagishi, Satoru
Fukuda, Atsuo
Sato, Kohji
Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title_full Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title_fullStr Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title_full_unstemmed Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title_short Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
title_sort orchestration of ion channels and transporters in neocortical development and neurological disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884360/
https://www.ncbi.nlm.nih.gov/pubmed/35237124
http://dx.doi.org/10.3389/fnins.2022.827284
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