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Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male

In this study, we report a case of a late-stage clival chordoma in a 29-year-old African American male and the unfortunate linear progression course since his initial diagnosis. Upon his initial encounter in 2020, radiation therapy did not offer any promising curative outcome. He was initially treat...

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Detalles Bibliográficos
Autores principales: Lopez, Olga, Al Ashi, Amro, Izquierdo-Pretel, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884465/
https://www.ncbi.nlm.nih.gov/pubmed/35242469
http://dx.doi.org/10.7759/cureus.21694
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author Lopez, Olga
Al Ashi, Amro
Izquierdo-Pretel, Guillermo
author_facet Lopez, Olga
Al Ashi, Amro
Izquierdo-Pretel, Guillermo
author_sort Lopez, Olga
collection PubMed
description In this study, we report a case of a late-stage clival chordoma in a 29-year-old African American male and the unfortunate linear progression course since his initial diagnosis. Upon his initial encounter in 2020, radiation therapy did not offer any promising curative outcome. He was initially treated with a combination treatment of partial resection, radiation, and proposed oral imatinib, none of which modified the natural history and progression of his illness. Instead, these methods were performed as palliative measures to reduce the current size of the tumors and decrease growth rates to minimize his pain. Social issues acted as a contributory risk factor in his prognosis and due to the patient's socioeconomic barriers, he was not able to continue seeking available radiotherapy, leading to disease exacerbation. Poor adherence was noted with his follow-up. The risks of being affected by this disease are likely multifactorial and more reports of such cases need to be added to bridge this gap in the current literature. In addition, there is a gap in the current study of reports of such tumors found in diverse racial groups and in patients who are in their first few decades of life. Novel treatment strategies were reviewed, and it is expected they could generate assertive treatment guidelines.
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spelling pubmed-88844652022-03-02 Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male Lopez, Olga Al Ashi, Amro Izquierdo-Pretel, Guillermo Cureus Neurology In this study, we report a case of a late-stage clival chordoma in a 29-year-old African American male and the unfortunate linear progression course since his initial diagnosis. Upon his initial encounter in 2020, radiation therapy did not offer any promising curative outcome. He was initially treated with a combination treatment of partial resection, radiation, and proposed oral imatinib, none of which modified the natural history and progression of his illness. Instead, these methods were performed as palliative measures to reduce the current size of the tumors and decrease growth rates to minimize his pain. Social issues acted as a contributory risk factor in his prognosis and due to the patient's socioeconomic barriers, he was not able to continue seeking available radiotherapy, leading to disease exacerbation. Poor adherence was noted with his follow-up. The risks of being affected by this disease are likely multifactorial and more reports of such cases need to be added to bridge this gap in the current literature. In addition, there is a gap in the current study of reports of such tumors found in diverse racial groups and in patients who are in their first few decades of life. Novel treatment strategies were reviewed, and it is expected they could generate assertive treatment guidelines. Cureus 2022-01-28 /pmc/articles/PMC8884465/ /pubmed/35242469 http://dx.doi.org/10.7759/cureus.21694 Text en Copyright © 2022, Lopez et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Lopez, Olga
Al Ashi, Amro
Izquierdo-Pretel, Guillermo
Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title_full Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title_fullStr Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title_full_unstemmed Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title_short Metastatic Clivus Chordoma: A Case of a Rare Tumor in a 29-Year-Old African American Male
title_sort metastatic clivus chordoma: a case of a rare tumor in a 29-year-old african american male
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884465/
https://www.ncbi.nlm.nih.gov/pubmed/35242469
http://dx.doi.org/10.7759/cureus.21694
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AT izquierdopretelguillermo metastaticclivuschordomaacaseofararetumorina29yearoldafricanamericanmale