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Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease

The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients with early-stage...

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Autores principales: Zeng, Weiqi, Fan, Wenliang, Kong, Xiangchuang, Liu, Xiaoming, Liu, Ling, Cao, Ziqin, Zhang, Xiaoqian, Yang, Xiaoman, Cheng, Chi, Wu, Yi, Xu, Yu, Cao, Xuebing, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884479/
https://www.ncbi.nlm.nih.gov/pubmed/35237144
http://dx.doi.org/10.3389/fnagi.2022.783634
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author Zeng, Weiqi
Fan, Wenliang
Kong, Xiangchuang
Liu, Xiaoming
Liu, Ling
Cao, Ziqin
Zhang, Xiaoqian
Yang, Xiaoman
Cheng, Chi
Wu, Yi
Xu, Yu
Cao, Xuebing
Xu, Yan
author_facet Zeng, Weiqi
Fan, Wenliang
Kong, Xiangchuang
Liu, Xiaoming
Liu, Ling
Cao, Ziqin
Zhang, Xiaoqian
Yang, Xiaoman
Cheng, Chi
Wu, Yi
Xu, Yu
Cao, Xuebing
Xu, Yan
author_sort Zeng, Weiqi
collection PubMed
description The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients with early-stage, drug-naïve PD and 50 HCs. Functional brain connectivity was analyzed at the integrity, network, and edge levels; UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores, reflecting the symptoms of PD, were collected for further regression analysis. Compared with age-matched HCs, reduced functional connectivity were mainly observed in the visual (VSN), somatomotor (SMN), limbic (LBN), and deep gray matter networks (DGN) at integrity level [p < 0.05, false discovery rate (FDR) corrected]. Intra-network analysis indicated decreased functional connectivity in DGN, SMN, LBN, and ventral attention networks (VAN). Inter-network analysis indicated reduced functional connectivity in nine pairs of resting-state networks. At the edge level, the LBN was the center of abnormal functional connectivity (p < 0.05, FDR corrected). MOCA score was associated with the intra-network functional connectivity strength (FC) of the DGN, and inter-network FC of the DGN-VAN. HAMA and HAMD scores were associated with the FC of the SMN and DGN, and either the LBN or VAN, respectively. We demonstrated variations in whole brain connections of drug-naïve patients with early PD. Major changes involved the SMN, DGN, LBN, and VSN, which may be relevant to symptoms of early PD. Additionally, our results support PD as a disconnection syndrome.
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spelling pubmed-88844792022-03-01 Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease Zeng, Weiqi Fan, Wenliang Kong, Xiangchuang Liu, Xiaoming Liu, Ling Cao, Ziqin Zhang, Xiaoqian Yang, Xiaoman Cheng, Chi Wu, Yi Xu, Yu Cao, Xuebing Xu, Yan Front Aging Neurosci Aging Neuroscience The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients with early-stage, drug-naïve PD and 50 HCs. Functional brain connectivity was analyzed at the integrity, network, and edge levels; UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores, reflecting the symptoms of PD, were collected for further regression analysis. Compared with age-matched HCs, reduced functional connectivity were mainly observed in the visual (VSN), somatomotor (SMN), limbic (LBN), and deep gray matter networks (DGN) at integrity level [p < 0.05, false discovery rate (FDR) corrected]. Intra-network analysis indicated decreased functional connectivity in DGN, SMN, LBN, and ventral attention networks (VAN). Inter-network analysis indicated reduced functional connectivity in nine pairs of resting-state networks. At the edge level, the LBN was the center of abnormal functional connectivity (p < 0.05, FDR corrected). MOCA score was associated with the intra-network functional connectivity strength (FC) of the DGN, and inter-network FC of the DGN-VAN. HAMA and HAMD scores were associated with the FC of the SMN and DGN, and either the LBN or VAN, respectively. We demonstrated variations in whole brain connections of drug-naïve patients with early PD. Major changes involved the SMN, DGN, LBN, and VSN, which may be relevant to symptoms of early PD. Additionally, our results support PD as a disconnection syndrome. Frontiers Media S.A. 2022-02-14 /pmc/articles/PMC8884479/ /pubmed/35237144 http://dx.doi.org/10.3389/fnagi.2022.783634 Text en Copyright © 2022 Zeng, Fan, Kong, Liu, Liu, Cao, Zhang, Yang, Cheng, Wu, Xu, Cao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Zeng, Weiqi
Fan, Wenliang
Kong, Xiangchuang
Liu, Xiaoming
Liu, Ling
Cao, Ziqin
Zhang, Xiaoqian
Yang, Xiaoman
Cheng, Chi
Wu, Yi
Xu, Yu
Cao, Xuebing
Xu, Yan
Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title_full Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title_fullStr Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title_full_unstemmed Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title_short Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
title_sort altered intra- and inter-network connectivity in drug-naïve patients with early parkinson’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884479/
https://www.ncbi.nlm.nih.gov/pubmed/35237144
http://dx.doi.org/10.3389/fnagi.2022.783634
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