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Synthesis of Isotopically Labeled, Spin-Isolated Tyrosine and Phenylalanine for Protein NMR Applications

[Image: see text] Isotopically labeled amino acids are widely used to study the structure and dynamics of proteins by NMR. Herein we describe a facile, gram-scale synthesis of compounds 1b and 2b under standard laboratory conditions from the common intermediate 7. 2b is obtained via simple deprotect...

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Detalles Bibliográficos
Autores principales:	Young, Brandon M., Rossi, Paolo, Slavish, P. Jake, Cui, Yixin, Sowaileh, Munia, Das, Jitendra, Kalodimos, Charalampos G., Rankovic, Zoran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884888/ https://www.ncbi.nlm.nih.gov/pubmed/34379431 http://dx.doi.org/10.1021/acs.orglett.1c02084

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