USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer’s disease (AD), implicating key roles for chromosome 21–encoded genes in the pathogenesis of AD. We previously identified a role for the deubiquitinase USP25, encoded on chromosome 21, in regulating micr...

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Detalles Bibliográficos
Autores principales: Zheng, Qiuyang, Song, Beibei, Li, Guilin, Cai, Fang, Wu, Meiling, Zhao, Yingjun, Jiang, LuLin, Guo, Tiantian, Shen, Mingyu, Hou, Huan, Zhou, Ying, Zhao, Yini, Di, Anjie, Zhang, Lishan, Zeng, Fanwei, Zhang, Xiu-Fang, Luo, Hong, Zhang, Xian, Zhang, Hongfeng, Zeng, Zhiping, Huang, Timothy Y., Dong, Chen, Qing, Hong, Zhang, Yun, Zhang, Qing, Wang, Xu, Wu, Yili, Xu, Huaxi, Song, Weihong, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884900/
https://www.ncbi.nlm.nih.gov/pubmed/35229730
http://dx.doi.org/10.1172/JCI152170

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