EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis

SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that govern SMAD3 activation. Here, we report that SMAD3 underwent methylation at K53 and K333 (K53/K333) by EZH2, a process...

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Detalles Bibliográficos
Autores principales: Huang, Changsheng, Hu, Fuqing, Song, Da, Sun, Xuling, Liu, Anyi, Wu, Qi, She, Xiaowei, Chen, Yaqi, Chen, Lisheng, Hu, Fayong, Xu, Feng, Luo, Xuelai, Feng, Yongdong, Yang, Xiangping, Hu, Junbo, Wang, Guihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884901/
https://www.ncbi.nlm.nih.gov/pubmed/35085106
http://dx.doi.org/10.1172/JCI152394

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