Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage

Anti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously demonstrated that acute deletion of 2 IBD susceptibility genes, A20 (Tnfaip3) an...

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Detalles Bibliográficos
Autores principales: Rusu, Iulia, Mennillo, Elvira, Bain, Jared L., Li, Zhongmei, Sun, Xiaofei, Ly, Kimberly M., Rosli, Yenny Y., Naser, Mohammad, Wang, Zunqiu, Advincula, Rommel, Achacoso, Philip, Shao, Ling, Razani, Bahram, Klein, Ophir D., Marson, Alexander, Turnbaugh, Jessie A., Turnbaugh, Peter J., Malynn, Barbara A., Ma, Averil, Kattah, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884902/
https://www.ncbi.nlm.nih.gov/pubmed/35077396
http://dx.doi.org/10.1172/JCI154993

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