Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demonstrated to coordinate the budding and formation o...

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Detalles Bibliográficos
Autores principales: Andersen, Rita C., Schmidt, Jan H., Rombach, Joscha, Lycas, Matthew D., Christensen, Nikolaj R., Lund, Viktor K., Stapleton, Donnie S., Pedersen, Signe S., Olsen, Mathias A., Stoklund, Mikkel, Noes-Holt, Gith, Nielsen, Tommas T.E., Keller, Mark P., Jansen, Anna M., Herlo, Rasmus, Pietropaolo, Massimo, Simonsen, Jens B., Kjærulff, Ole, Holst, Birgitte, Attie, Alan D., Gether, Ulrik, Madsen, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884907/
https://www.ncbi.nlm.nih.gov/pubmed/35077398
http://dx.doi.org/10.1172/JCI144904

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